Weber-Christian Disease Treatment & Management

Updated: Oct 07, 2019
  • Author: Donald A Person, MD, FAAP, FACR; Chief Editor: Lawrence K Jung, MD  more...
  • Print
Treatment

Medical Care

No uniformly effective therapy for Weber-Christian disease is known. Clinical experience, especially in children and adolescents, has pointed to the value of corticosteroids and immunosuppressive agents.

Therapeutic responses have been reported with the use of fibrinolytic agents, hydroxychloroquine, azathioprine, thalidomide, cyclophosphamide, tetracycline, cyclosporine, mycophenolate, and clofazimine.

Systemic steroids (eg, prednisone) may be effective in suppressing acute exacerbations.

Nonsteroidal anti-inflammatory agents may reduce fever, arthralgias, and other signs of malaise.

Involvement of specific organs may require specific supportive drugs.

Inpatient hospitalization and supportive care may be necessary in severe cases of Weber-Christian disease in which inflammation involves visceral organs or for wound care, as indicated.

Next:

Surgical Care

No surgical treatment is indicated.

Previous
Next:

Consultations

Consultation with a pediatric dermatologist will help in considering differential diagnoses and possible causes of panniculitis. The dermatologist may also perform a skin biopsy for pathological review.

Consultation with a pediatric rheumatologist and infectious disease specialist will help to determine a differential diagnosis and implement a treatment regimen.

Previous
Next:

Diet

No specific dietary requirements are noted.

Previous
Next:

Activity

Activity is ad lib, and trauma to the affected areas should be avoided.

Previous
Next:

Prevention

No effective methods of prevention have been discovered.

Previous
Next:

Long-Term Monitoring

Monitor individuals with Weber-Christian disease for progression of the disease and for adverse effects of medications. Routine follow-up care is indicated.

Previous