LSD Toxicity Differential Diagnoses

Updated: Dec 29, 2015
  • Author: Paul P Rega, MD, FACEP; Chief Editor: Timothy E Corden, MD  more...
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DDx

Diagnostic Considerations

Toxins to consider in the differential diagnosis of lysergic acid diethylamide (LSD) toxicity include the following:

  • Other psychedelics or entactogens
  • N,N-dimethyltryptamine (DMT)
  • 4-Methyl-2,5-dimethoxyamphetamine (STP, DOM, serenity, tranquility, peace)
  • 3,4-Methylenedioxyamphetmine (MDA)
  • 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy, Adam)
  • 3,4-Methylenedioxyethamphetamine (MDEA, Eve)
  • Mescaline
  • Psilocybin
  • Anticholinergics (atropine, jimsonweed)
  • Sympathomimetics ( cocaine, amphetamines)
  • Others - Steroids, yohimbine, bufotenine (toads), nutmeg, or hallucinogenic mushrooms
  • Sedative-hypnotic withdrawal (ethanol, benzodiazepines, barbiturates, gamma-hydroxybutyrate [GHB])

Metabolic conditions to consider in the differential diagnosis of LSD toxicity include the following:

  • Hypoxia
  • Hypoglycemia
  • Electrolyte abnormalities

Other conditions to consider in the differential diagnosis of LSD toxicity include the following:

  • Schizophrenia
  • Psychosis
  • Heat-related illnesses
  • CNS infection
  • CNS neoplasms
  • Thyrotoxicosis
  • Encephalitis
  • Aseptic meningitis

Differential Diagnoses