Hypospadias Workup

Updated: Oct 04, 2023
  • Author: John Michael Gatti, MD; Chief Editor: Marc Cendron, MD  more...
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Laboratory Studies

No laboratory tests have been found to be helpful in the evaluation and management of hypospadias. In cases where a difference (disorder) of sex development (DSD) is suspected, hormonal evaluation may be needed.


Imaging Studies

Anomalies of the upper urinary tract are rarely associated with hypospadias and do not justify routine imaging in these patients unless other organ system anomalies are present. Other associated findings are more common (eg, enlarged prostatic utricle, low-grade vesicoureteral reflux [VUR]) but are of little consequence clinically unless other symptoms merit evaluation. [36]

It has been argued that prostatic utricles are an underappreciated cause of urologic morbidity and may present as penile pain with voiding, hematuria, epididymitis, and urinary tract infection (UTI) and therefore should be sought with retrograde urethrography in the setting of proximal hypospadias. [37]



In very rare instances, presence of meatal stenosis may prevent normal egress of urine and cause distal ballooning of the urethra. This may necessitate a temporizing meatoplasty to allow normal flow of urine.