Medication
Medication Summary
Medications used in disorders of sex development (DSDs) depend on the underlying cause.
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Glucocorticoids
Class Summary
These agents have anti-inflammatory properties and cause profound and varied metabolic effects. They modify the body's immune response to diverse stimuli. Children with congenital adrenal hyperplasia (CAH) require corticosteroid replacement for survival. Replacement also reduces the production of corticotropin and, therefore, the overproduction of androgens.
Hydrocortisone (Hydrocortone, Cortef)
Drug of choice because of mineralocorticoid activity and glucocorticoid effects.
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Media Gallery
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Patient with 46,XX disorder of sex development (DSD). Note masculinized appearance of genitalia, with enlarged phallus and scrotal appearance of labia.
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Patient with congenital adrenal hyperplasia (CAH; 46,XX DSD). Note phalluslike clitoris and empty scrotal appearance of labia majora.
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Same patient with congenital adrenal hyperplasia (CAH; 46,XX DSD), after feminizing genitoplasty surgery. Note achievement of three components of surgery: clitoroplasty, vaginoplasty. and labiaplasty. Upper catheter is in urethra and lower one in vagina.
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