Chronic Urticaria Questions & Answers

1. Dreyfus DH, Schocket AL, Milgrom H. Steroid-resistant chronic urticaria associated with anti-thyroid microsomal antibodies in a nine-year-old boy. J Pediatr. 1996 Apr. 128(4):576-8. [QxMD MEDLINE Link].

2. Ellis MH. Successful treatment of chronic urticaria with leukotriene antagonists. J Allergy Clin Immunol. 1998 Nov. 102(5):876-7. [QxMD MEDLINE Link].

3. Spector S, Tan RA. Antileukotrienes in chronic urticaria. J Allergy Clin Immunol. 1998 Apr. 101(4 Pt 1):572. [QxMD MEDLINE Link].

4. [Guideline] Powell RJ, Du Toit GL, Siddique N, et al. BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy. 2007 May. 37(5):631-50. [QxMD MEDLINE Link].

5. Morgan M, Khan DA. Therapeutic alternatives for chronic urticaria: an evidence-based review, part 1. Ann Allergy Asthma Immunol. 2008 May. 100(5):403-11; quiz 412-4, 468. [QxMD MEDLINE Link].

6. Kozel MM, Bossuyt PM, Mekkes JR, Bos JD. Laboratory tests and identified diagnoses in patients with physical and chronic urticaria and angioedema: A systematic review. J Am Acad Dermatol. 2003 Mar. 48 (3):409-16. [QxMD MEDLINE Link].

7. Kaplan AP, Greaves M. Pathogenesis of chronic urticaria. Clin Exp Allergy. 2009 Jun. 39(6):777-87. [QxMD MEDLINE Link].

8. Pham DL, Lim KM, Joo KM, Park HS, Leung DYM, Ye YM. Increased cis-to-trans urocanic acid ratio in the skin of chronic spontaneous urticaria patients. Sci Rep. 2017 May 2. 7 (1):1318. [QxMD MEDLINE Link].

9. Bernstein JA, Lang DM, Khan DA, Craig T, Dreyfus D, Hsieh F, et al. The diagnosis and management of acute and chronic urticaria: 2014 update. J Allergy Clin Immunol. 2014 May. 133 (5):1270-7. [QxMD MEDLINE Link].

10. Bossi F, Frossi B, Radillo O, et al. Mast cells are critically involved in serum-mediated vascular leakage in chronic urticaria beyond high-affinity IgE receptor stimulation. Allergy. 2011 Dec. 66(12):1538-1545. [QxMD MEDLINE Link].

11. Mathelier-Fusade P. Drug-induced urticarias. Clin Rev Allergy Immunol. 2006 Feb. 30(1):19-23. [QxMD MEDLINE Link].

12. Heymann WR. Chronic urticaria and angioedema associated with thyroid autoimmunity: review and therapeutic implications. J Am Acad Dermatol. 1999 Feb. 40(2 Pt 1):229-32. [QxMD MEDLINE Link].

13. Bansal AS, Hayman GR. Graves disease associated with chronic idiopathic urticaria: 2 case reports. J Investig Allergol Clin Immunol. 2009. 19(1):54-6. [QxMD MEDLINE Link].

14. Ryhal B, DeMera RS, Shoenfeld Y, Peter JB, Gershwin ME. Are autoantibodies present in patients with subacute and chronic urticaria?. J Investig Allergol Clin Immunol. 2001. 11 (1):16-20. [QxMD MEDLINE Link].

15. Kasumagic-Halilovic E, Beslic N, Ovcina-Kurtovic N. Thyroid Autoimmunity in Patients with Chronic Urticaria. Med Arch. 2017 Feb. 71 (1):29-31. [QxMD MEDLINE Link].

16. Palma-Carlos AG, Palma-Carlos ML. Chronic urticaria and thyroid auto-immunity. Eur Ann Allergy Clin Immunol. 2005 Apr. 37 (4):143-6. [QxMD MEDLINE Link].

17. Tebbe B, Geilen CC, Schulzke JD, Bojarski C, Radenhausen M, Orfanos CE. Helicobacter pylori infection and chronic urticaria. J Am Acad Dermatol. 1996 Apr. 34(4):685-6. [QxMD MEDLINE Link].

18. Valsecchi R, Pigatto P. Chronic urticaria and Helicobacter pylori. Acta Derm Venereol. 1998 Nov. 78(6):440-2. [QxMD MEDLINE Link].

19. Campanati A, Gesuita R, Giannoni M, Piraccini F, Sandroni L, Martina E, et al. Role of small intestinal bacterial overgrowth and Helicobacter pylori infection in chronic spontaneous urticaria: a prospective analysis. Acta Derm Venereol. 2013 Mar 27. 93 (2):161-4. [QxMD MEDLINE Link].

20. Ventura MT, Napolitano S, Menga R, Cecere R, Asero R. Anisakis simplex Hypersensitivity Is Associated with Chronic Urticaria in Endemic Areas. Int Arch Allergy Immunol. 2013. 160(3):297-300. [QxMD MEDLINE Link].

21. Baty V, Hoen B, Hudziak H, Aghassian C, Jeandel C, Canton P. Schnitzler's syndrome: two case reports and review of the literature. Mayo Clin Proc. 1995 Jun. 70(6):570-2. [QxMD MEDLINE Link].

22. Sigurgeirsson B. Skin disease and malignancy. An epidemiological study. Acta Derm Venereol Suppl (Stockh). 1992. 178:1-110. [QxMD MEDLINE Link].

23. Chen YJ, Wu CY, Shen JL, Chen TT, Chang YT. Cancer risk in patients with chronic urticaria: a population-based cohort study. Arch Dermatol. 2012 Jan. 148 (1):103-8. [QxMD MEDLINE Link].

24. Torresani C, Bellafiore S, De Panfilis G. Chronic urticaria is usually associated with fibromyalgia syndrome. Acta Derm Venereol. 2009. 89(4):389-92. [QxMD MEDLINE Link].

25. O'Donnell BF, O'Neill CM, Francis DM, Niimi N, Barr RM, Barlow RJ, et al. Human leucocyte antigen class II associations in chronic idiopathic urticaria. Br J Dermatol. 1999 May. 140 (5):853-8. [QxMD MEDLINE Link].

26. Kozel MM, Mekkes JR, Bossuyt PM, Bos JD. Natural course of physical and chronic urticaria and angioedema in 220 patients. J Am Acad Dermatol. 2001 Sep. 45 (3):387-91. [QxMD MEDLINE Link].

27. Yosipovitch G, Greaves M. Chronic idiopathic urticaria: a "Cinderella" disease with a negative impact on quality of life and health care costs. Arch Dermatol. 2008 Jan. 144(1):102-3. [QxMD MEDLINE Link].

28. O'Donnell BF, Lawlor F, Simpson J, Morgan M, Greaves MW. The impact of chronic urticaria on the quality of life. Br J Dermatol. 1997 Feb. 136(2):197-201. [QxMD MEDLINE Link].

29. Maurer M, Ortonne JP, Zuberbier T. Chronic urticaria: a patient survey on quality-of-life, treatment usage and doctor-patient relation. Allergy. 2009 Apr. 64(4):581-8. [QxMD MEDLINE Link].

30. Brodell LA, Beck LA. Differential diagnosis of chronic urticaria. Ann Allergy Asthma Immunol. 2008 Mar. 100(3):181-8; quiz 188-90, 215. [QxMD MEDLINE Link].

31. Kanazawa K, Yaoita H, Tsuda F, Okamoto H. Hepatitis C virus infection in patients with urticaria. J Am Acad Dermatol. 1996 Aug. 35(2 Pt 1):195-8. [QxMD MEDLINE Link].

32. Zuberbier T, Asero R, Bindslev-Jensen C, Walter Canonica G, Church MK, Giménez-Arnau A, et al. EAACI/GA(2)LEN/EDF/WAO guideline: definition, classification and diagnosis of urticaria. Allergy. 2009 Oct. 64(10):1417-26. [QxMD MEDLINE Link].

33. Patil AD, Bingewar G, Goldust M. Efficacy of methotrexate as add on therapy to H1 antihistamine in difficult to treat chronic urticaria: A systematic review and meta-analysis of randomized clinical trials. Dermatol Ther. 2020 Nov. 33 (6):e14077. [QxMD MEDLINE Link].

34. Su O, Bahali AG, Onsun N. The effect of at least 1-year use of omalizumab without interruption on relapse in patients with chronic spontaneous urticaria. Dermatol Ther. 2020 Nov. 33 (6):e14192. [QxMD MEDLINE Link].

35. Maoz-Segal R, Levy T, Haj-Yahia S, Offengenden I, Iancovich-Kidon M, Agmon-Levin N. Combination therapy with omalizumab and an immune-suppressive agent for resistant chronic spontaneous rrticaria - A real-life experience. World Allergy Organ J. 2020 Aug. 13 (8):100448. [QxMD MEDLINE Link].

36. Agache I, Rocha C, Pereira A, et al. Efficacy and safety of treatment with omalizumab for chronic spontaneous urticaria: A systematic review for the EAACI Biologicals Guidelines. Allergy. 2021 Jan. 76 (1):59-70. [QxMD MEDLINE Link]. [Full Text].

37. Sarti L, Barni S, Giovannini M, Liccioli G, Novembre E, Mori F. Efficacy and tolerability of the updosing of second-generation non-sedating H1 antihistamines in children with chronic spontaneous urticaria. Pediatr Allergy Immunol. 2021 Jan. 32 (1):153-160. [QxMD MEDLINE Link].

38. Egan CA, Rallis TM. Treatment of chronic urticaria with ketotifen. Arch Dermatol. 1997 Feb. 133(2):147-9. [QxMD MEDLINE Link].

39. Jauregui I, Ferrer M, Montoro J, et al. Antihistamines in the treatment of chronic urticaria. J Investig Allergol Clin Immunol. 2007. 17 Suppl 2:41-52. [QxMD MEDLINE Link].

40. Grob JJ, Auquier P, Dreyfus I, Ortonne JP. How to prescribe antihistamines for chronic idiopathic urticaria: desloratadine daily vs PRN and quality of life. Allergy. 2009 Apr. 64(4):605-12. [QxMD MEDLINE Link].

41. Staevska M, Popov TA, Kralimarkova T, Lazarova C, Kraeva S, Popova D, et al. The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficult-to-treat urticaria. J Allergy Clin Immunol. 2010 Mar. 125(3):676-82. [QxMD MEDLINE Link].

42. Maurer M, Rosén K, Hsieh HJ, Saini S, Grattan C, Gimenéz-Arnau A, et al. Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria. N Engl J Med. 2013 Mar 7. 368(10):924-35. [QxMD MEDLINE Link].

43. Brooks M. FDA OKs Omalizumab (Xolair) for Chronic Hives. Medscape Medical News. Mar 21 2014. [Full Text].

44. Rorie A, Goldner WS, Lyden E, Poole JA. Beneficial role for supplemental vitamin D3 treatment in chronic urticaria: a randomized study. Ann Allergy Asthma Immunol. 2014 Feb 5. [QxMD MEDLINE Link].

45. Janeczko LL. High-dose vitamin D supplements may benefit people with chronic urticaria. Reuters Health Information. February 24, 2014. [Full Text].

46. Kitsioulis NA, Xepapadaki P, Roussaki-Schulze AV, Papadopoulos N, Zafiriou E. Effectiveness of Autologous Whole-Blood Injections in Patients with Refractory Chronic Spontaneous Urticaria. Int Arch Allergy Immunol. 2017. 172 (3):161-166. [QxMD MEDLINE Link].

47. Moolani Y, Lynde C, Sussman G. Advances in Understanding and Managing Chronic Urticaria. F1000Res. 2016. 5:[QxMD MEDLINE Link].

48. [Guideline] Powell RJ, Leech SC, Till S, Huber PA, Nasser SM, Clark AT. BSACI guideline for the management of chronic urticaria and angioedema. Clin Exp Allergy. 2015 Mar. 45(3):547-65. [QxMD MEDLINE Link].

Marla N Diakow, MD Resident Physician, Department of Dermatology, State University of New York Downstate College of Medicine

Marla N Diakow, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association

Disclosure: Nothing to disclose.

Jeannette Rachel Jakus, MD, MBA Clinical Assistant Professor, Director of Clinical Research, Assistant Program Director, Department of Dermatology, SUNY Downstate Medical Center; Dermatologist, Brody Dermatology

Jeannette Rachel Jakus, MD, MBA is a member of the following medical societies: American Academy of Dermatology, American Academy of Pediatrics, American Skin Association, Society for Pediatric Dermatology, Women's Dermatologic Society

Disclosure: Nothing to disclose.

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology, Society for Investigative Dermatology

Disclosure: Received income in an amount equal to or greater than $250 from: Elsevier; WebMD<br/>Served as a speaker for various universities, dermatology societies, and dermatology departments.

Daniel J Hogan, MD Clinical Professor of Internal Medicine (Dermatology), Nova Southeastern University College of Osteopathic Medicine; Investigator, Hill Top Research, Florida Research Center

Daniel J Hogan, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Contact Dermatitis Society, Canadian Dermatology Association

Disclosure: Nothing to disclose.

Warren R Heymann, MD Head, Division of Dermatology, Professor, Department of Internal Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School

Warren R Heymann, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, and Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Robert A Schwartz, MD, MPH Professor and Head, Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, University of Medicine and Dentistry of New Jersey-New Jersey Medical School

Robert A Schwartz, MD, MPH is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American College of Physicians, and Sigma Xi

Disclosure: Nothing to disclose.

Dina D Strachan, MD Assistant Clinical Professor, Department of Dermatology, St Vincent's Medical Center

Dina Strachan, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Richard P Vinson, MD Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Association of Military Dermatologists, Texas Dermatological Society, and Texas Medical Association

Disclosure: Nothing to disclose.

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