Common Variable Immunodeficiency Medication

Updated: Jun 08, 2022
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Medication Summary

The goals of pharmacotherapy for common variable immunodeficiency (CVID) are to reduce morbidity and prevent complications. Treatment with rapamycin has been suggested, but this therapy awaits proper evaluation. [51] Rituximab has been used to treat associated hemolytic anemia and thrombocytopenia. [52] Additionally, Lin et al reported on the treatment of CVID-associated cutaneous granuloma using etanercept. [53]



Class Summary

Ig passively supplies recipients with a broad spectrum of IgG antibodies against bacteria, viruses, and parasites.

Immune globulin intravenous (Gamimune, Gammar-P, Sandoglobulin, Gammagard S/D)

Intravenous immune globulin neutralizes circulating myelin antibodies with anti-idiotypic antibodies. It down-regulates proinflammatory cytokines, including interferon-gamma. It blocks Fc receptors on macrophages and blocks the complement cascade. It suppresses inducer T and B cells and augments suppressor T cells. It also promotes remyelination and may increase CSF IgG levels by 10%.