Common Variable Immunodeficiency Medication

Updated: Mar 17, 2020
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Medication

Medication Summary

The goals of pharmacotherapy for common variable immunodeficiency (CVID) are to reduce morbidity and prevent complications. Treatment with rapamycin has been suggested, but this therapy awaits proper evaluation. [48] Rituximab has been used to treat associated hemolytic anemia and thrombocytopenia. [49] Additionally, Lin et al reported on the treatment of CVID-associated cutaneous granuloma using etanercept. [50]

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Immunoglobulins

Class Summary

Ig passively supplies recipients with a broad spectrum of IgG antibodies against bacteria, viruses, and parasites.

Immune globulin intravenous (Gamimune, Gammar-P, Sandoglobulin, Gammagard S/D)

Intravenous immune globulin neutralizes circulating myelin antibodies with anti-idiotypic antibodies. It down-regulates proinflammatory cytokines, including interferon-gamma. It blocks Fc receptors on macrophages and blocks the complement cascade. It suppresses inducer T and B cells and augments suppressor T cells. It also promotes remyelination and may increase CSF IgG levels by 10%.

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