Erythrasma Medication

Updated: Jun 11, 2020
  • Author: Abdul-Ghani Kibbi, MD, FACP; Chief Editor: William D James, MD  more...
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Medication

Medication Summary

The goals of pharmacotherapy for erythrasma are to reduce morbidity, eradicate the infection, and prevent complications.

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Antibiotics

Class Summary

Antibacterial and/or antifungal agents are used to eradicate C minutissimum and possible concomitant infection.

Erythromycin (E.E.S., E-Mycin, Ery-Tab)

Erythromycin is the drug of choice. It inhibits bacterial growth, possibly by blocking dissociation of peptidyl t-RNA from ribosomes, causing RNA-dependent protein synthesis to arrest. In children, age, weight, and severity of infection determine the proper dosage. When twice-daily dosing is desired, half the total daily dose may be taken every 12 hours. For more severe infections, double the dose.

Clarithromycin (Biaxin)

Clarithromycin inhibits bacterial growth, possibly by blocking dissociation of peptidyl t-RNA from ribosomes, causing RNA-dependent protein synthesis to arrest.

Clindamycin (Cleocin)

Clindamycin has a bacteriostatic effect; it interferes with bacterial protein synthesis similarly to erythromycin and chloramphenicol by binding to the 50S subunit of bacterial ribosomes.

Tetracycline (Achromycin)

Tetracycline inhibits cell growth by inhibiting mRNA translation. It binds to the 16S part of 30S ribosomal subunits and prevents amino-acyl tRNA from binding to the A site of ribosomes. Binding is reversible in nature.

Clindamycin topical (Cleocin T, Clindacin P, ClindaDerm)

Clindamycin is an antibacterial agent that binds to the 50S ribosomal subunits of susceptible bacteria and prevents elongation of peptide chains by interfering with peptidyl transfer, thereby suppressing protein synthesis.

Erythromycin topical (AkneMycin, Ery)

Erythromycin inhibits protein synthesis in susceptible organisms by reversibly binding to 50 S ribosomal subunits, thereby inhibiting translocation of aminoacyl transfer-RNA and inhibiting polypeptide synthesis.

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Antifungals

Class Summary

Antibacterial and/or antifungal agents are used to eradicate C minutissimum and possible concomitant infection.

Miconazole topical (Femazole, Lotrimin, Monistat)

Miconazole damages the fungal cell wall membrane by inhibiting the biosynthesis of ergosterol. Membrane permeability is increased, causing nutrients to leak out and resulting in fungal cell death. Lotion is preferred in intertriginous areas. If cream is used, apply sparingly to avoid maceration effects. Use 2% cream.

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