Dermatologic Manifestations of Staphylococcal Scalded Skin Syndrome Differential Diagnoses

Updated: Mar 15, 2022
  • Author: Elizabeth U Rogozinski, MD, MS; Chief Editor: Dirk M Elston, MD  more...
  • Print

Diagnostic Considerations

In a case report, Davey et al point out that staphylococcal scalded skin syndrome (SSSS) and toxic epidermal necrolysis have a nearly identical clinical presentation in adult patients. However, the base of SSSS blisters tends to be the same color as the surrounding skin, while the base of blisters in toxic epidermal necrolysis trends toward pink or white with the surrounding skin being a darker color. Additionally, on histology, SSSS shows subcorneal bullae with little to no inflammation, while toxic epidermal necrolysis exhibits dermal-epidermal blisters with focal dyskeratosis along with areas of full-thickness necrosis throughout the epidermis. [40]

Differential Diagnoses