Trichomycosis Pubis Medication

Updated: Aug 25, 2017
  • Author: Jeannette Rachel Jakus, MD, MBA; Chief Editor: Dirk M Elston, MD  more...
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Medication

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications. Fusidic acid is a steroid antibiotic that is often used topically in creams and eyedrops but may also be given systemically as tablets or injections. It is not available in the United States.

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Antifungals

Class Summary

Mechanism of action usually involves inhibiting pathways (enzymes, substrates, transport) necessary for sterol/cell membrane synthesis or altering the permeability of the cell membrane (polyenes) of the fungal cell.

Naftifine (Naftin)

Naftifine is a synthetic allylamine derivative shown to exhibit fungicidal activity in vitro against a broad spectrum of organisms, including species of Trichophyton, Microsporum, and Epidermophyton genera. Naftifine has shown fungistatic activity against Candida species. The exact mechanism of action is not known; however, it appears to interfere with sterol biosynthesis by inhibiting squalene 2,3-epoxidase. Treatment should continue for up to 4 weeks. If no improvement is noted, re-evaluate the patient.

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Antimicrobials

Class Summary

Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the context of the clinical setting. Antibiotic selection should be guided by blood culture sensitivity whenever feasible.

Clindamycin solution (Cleocin T, Clinda-Derm)

Clindamycin solution is a wide-spectrum antibiotic effective in vivo against various microbial organisms, including Corynebacterium species. This antibiotic binds preferentially to the 50S ribosomal subunit, affecting the process of peptide chain initiation in bacteria.

Benzoyl peroxide (Benoxyl, Fostex, Benzac)

With benzoyl peroxide, a free-radical oxygen is released upon administration and oxidizes bacterial proteins in sebaceous follicles, decreasing the number of anaerobic bacterial and irritating free fatty acids. It has keratolytic and comedolytic effects. Use gel, pads, or wash.

Erythromycin topical (AkneMycin, Ery)

Erythromycin inhibits bacterial growth, possibly by blocking dissociation of peptidyl t-RNA from ribosomes, causing RNA-dependent protein synthesis to arrest.

Sulfur topical (Aqua KAVI, De La Cruz Sulfur Ointment, Grandpa's Thylox Acne Treatment Soap with Sulfur)

Sulfur soaps have been reported to be effective in the treatment and prevention of trichomycosis.

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Astringents

Class Summary

Agents that work to dry up the sweat glands.

Aluminum chloride topical (Xerac-AC roll-on, Certain-dry pads, Drysol solution)

Aluminum chloride topical is an astringent agent used in the management of hyperhidrosis.

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