Dermatologic Manifestations of Lymphogranuloma Venereum Medication

Updated: May 10, 2018
  • Author: Jose A Plaza, MD; Chief Editor: Dirk M Elston, MD  more...
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Medication

Medication Summary

The goal of pharmacotherapy for lymphogranuloma venereum (LGV) is to reduce morbidity and to prevent complications.

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Antibiotics

Class Summary

Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the context of the clinical setting.

Doxycycline (Doryx, Bio-Tab)

Doxycycline inhibits protein synthesis in bacteria by binding to the 30S and possibly the 50S ribosomal subunits.

Erythromycin base (Erythrocin)

Erythromycin base inhibits RNA-dependent protein synthesis, possibly by stimulating the dissociation of peptidyl t-RNA from ribosomes. This inhibits bacterial growth (ie, erythromycin is bacteriostatic, not bacteriocidal). In children, consider age, weight, and severity of infection to determine proper dosage. When twice-daily dosing is desired, half the total daily dose may be taken every 12 hours. For more severe infections, the dose may be doubled.

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