Connective Tissue Nevus Treatment & Management

Updated: Mar 05, 2018
  • Author: Steven Brett Sloan, MD; Chief Editor: Dirk M Elston, MD  more...
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Medical Care

A biopsy may be indicated for diagnostic purposes. One case report has described a linear nodular collagenoma treated successfully with intralesional triamcinolone. [9]


Surgical Care

Surgical excision is necessary when the patient would like the lesion removed for cosmetic reasons; however, surgery may not be advised when multiple or large lesions are present.



For connective tissue nevi unassociated with a syndrome, no additional consultation is required. Other consultations are as follows:

  • Internal medicine/pediatric specialists: Patients with tuberous sclerosis, Proteus syndrome, or Hunter syndrome may have multiple organ system involvement and should receive a complete medical evaluation.

  • Orthopedic surgeon: A bone biopsy may be needed to determine the nature of the bony lesions in patients with suspected Buschke-Ollendorf syndrome. Patients with Buschke-Ollendorf syndrome may also develop joint contractures over areas of melorheostosis. Patients with Hunter syndrome should be screened for musculoskeletal involvement.

  • Neurologist: Patients with tuberous sclerosis and Hunter syndrome should be screened for CNS involvement.

  • Ophthalmologist: Patients with tuberous sclerosis may have retinal hamartomas.