Infantile Digital Fibromatosis Medication

Updated: Apr 11, 2019
  • Author: Monique Gupta Kumar, MD, MPhil; Chief Editor: Dirk M Elston, MD  more...
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Medication

Medication Summary

Topical corticosteroids with or without occlusion have not shown any benefit in infantile digital fibromatosis; however, intralesional corticosteroids or fluorouracil may prove beneficial. [14, 15]

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Corticosteroids

Class Summary

Anti-inflammatory agents may induce regression of dermal infiltrative lesions.

Triamcinolone (Aristocort)

Triamcinolone is used for inflammatory dermatosis responsive to steroids. It decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing capillary permeability. Triamcinolone can be injected intralesionally.

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Antimetabolites

Class Summary

These agents inhibit cell growth and proliferation.

Fluorouracil (Efudex, Adrucil, Fluoroplex)

Fluorouracil is a pyrimidine analogue that has been shown to inhibit dermal fibroblast proliferation and collagen synthesis in cell culture.

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