Leiomyoma Differential Diagnoses

Updated: Jun 15, 2021
  • Author: Fnu Nutan, MD, FACP; Chief Editor: William D James, MD  more...
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Diagnostic Considerations

Also consider the following:

  • Angiolipoma
  • Adnexal tumor
  • Cylindroma
  • Dermal nevi
  • Dermatofibroma/dermatomyofibroma
  • Neuroma
  • Giant cell tumor
  • Glomus tumor
  • Hamartoma
  • Keloids
  • Eccrine spiradenoma
  • Fibrosed epidermoid inclusion cyst
  • Breast carcinoma (differential diagnosis of leiomyoma involving areola or nipple)
  • Lipoma
  • Poroma
  • Trichoepithelioma
  • Plasmacytoma
  • Neurofibroma
  • Nevus

Multiple cutaneous and uterine leiomyomatosis (ie, MCUL or Reed syndrome) is present in women with multiple cutaneous piloleiomyomas and uterine leiomyomas. Pain can be problematic in these patients, who are frequently not surgical candidates because of the location and enormous number of tumors. Polycythemia may be associated with multiple leiomyomas in rare cases. This phenomenon may be due to tumor production of an erythropoietinlike substance.

Differential Diagnoses