Cutaneous Lipomas Differential Diagnoses

Updated: Jan 27, 2020
  • Author: Marjon Vatanchi, MD; Chief Editor: William D James, MD  more...
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Diagnostic Considerations

Also consider the following:

  • Lipoblastomas
  • Liposarcomas [11] : This is the most common soft-tissue malignancy in adults. Liposarcomas rarely arise in a preexisting lipoma and appear in middle-aged or elderly adults. A liposarcoma can present as a rapidly growing nonmobile mass that is painful, owing to its compression of nerves. The overlying skin can become ulcerated. If a liposarcoma is suspected, perform a fine-needle aspiration or biopsy to confirm the diagnosis.
  • Spindle cell adenolipoma, a rare variant of cutaneous lipomas [12]
  • Chondroid lipoma, a benign entity that can be misdiagnosed as sarcoma on histopathology [13]
  • Cutaneous intramuscular lipoma, rare variant with few reported cases worldwide [14]
  • Neurofibromas
  • Epidermoid cysts (occasionally)
  • Obesity
  • Sialadenitis
  • Goiter
  • Lymphatic tumor
  • Dermatofibromas (occasionally)
  • Blue rubber bleb nevus, eccrine spiradenoma, neuroma, neurofibromas, glomus tumors, granular cell tumors, angiolipomas, leiomyoma; also termed BENGAL

Differential Diagnoses