Mastocytosis Medication

Updated: Jun 07, 2018
  • Author: Jacquiline Habashy, DO, MSc; Chief Editor: Dirk M Elston, MD  more...
  • Print
Medication

Medication Summary

Tailor therapy according to the patient's specific needs for symptomatic relief. Patients may be started on oral H1 antihistamine and/or oral disodium cromoglycate with or without the use of a potent topical steroid for selected cutaneous lesions. In patients with a limited number of lesions, intralesional corticosteroid injections are an additional therapeutic option. Oral histamine H2 antagonists may be administered in addition to an oral H1 antihistamine.

Next:

Antihistamines

Class Summary

Antihistamines relieve pruritus and flushing.

Hydroxyzine (Atarax, Atozine, Vistaril)

Hydroxyzine antagonizes H1 receptors in the periphery. It may suppress histamine activity in the subcortical region of the CNS.

Previous
Next:

Mast cell stabilizers

Class Summary

Cromolyn is a mast cell stabilizer that improves diarrhea, flushing, headaches, vomiting, urticaria, abdominal pain, nausea, and itching in some patients.

Cromolyn sodium (Gastrocrom)

Cromolyn sodium inhibits degranulation of sensitized mast cells following exposure to specific antigens. It is available as an oral concentrate solution in 5-mL ampules to mix with water and is administered at least 30 minutes before eating. Each 5-mL ampule contains 100 mg of cromolyn sodium, USP, in purified water. Each foil pouch contains 8 ampules.

Previous
Next:

Histamine H2 antagonists

Class Summary

The addition of H2 antagonist to H1 antagonist helps control pruritus and whealing. In addition, GI symptoms associated with hyperchlorhydria, such as peptic ulcer disease and gastritis, respond well to this medication.

Cimetidine (Tagamet)

Cimetidine is an H2 antagonist that when combined with an H1 type may be useful in treating itching and flushing in urticaria and contact dermatitis that do not respond to H1 antagonists alone. Use cimetidine in addition to H1 antihistamines.

Previous
Next:

Vasopressors

Class Summary

Vasopressors are for patients with systemic disease or extensive symptoms.

Epinephrine (EpiPen)

Epinephrine is the drug of choice for treating anaphylactoid reactions. It has alpha-agonist effects that include increased peripheral vascular resistance, reversed peripheral vasodilatation, systemic hypotension, and vascular permeability. Its beta-agonist effects include bronchodilatation, chronotropic cardiac activity, and positive inotropic effects.

Previous