Mastocytosis Questions & Answers

Updated: Jun 07, 2018
  • Author: Jacquiline Habashy, DO, MSc; Chief Editor: Dirk M Elston, MD  more...
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Questions & Answers

Overview

What is mastocytosis?

What are the WHO classifications of mastocytosis?

What are the WHO criteria for cutaneous mastocytosis?

What are the types of cutaneous mastocytosis?

What is the Darier sign in mastocytosis?

What is the pathophysiology of mastocytosis?

What causes mastocytosis?

What is the prevalence of mastocytosis?

What are the racial predilections of mastocytosis by?

How does the prevalence of mastocytosis vary by sex?

How does the prevalence of mastocytosis vary by age?

What is the prognosis of mastocytosis?

What is included in the patient education about mastocytosis?

Presentation

Which clinical history findings are characteristic of mastocytosis?

Which distribution of skin lesions is characteristic of mastocytosis?

How are skin lesions characterized in mastocytosis?

Which skin lesion characteristics indicate mastocytosis?

What are noncutaneous systemic findings that suggest mastocytosis?

What are complications of mastocytosis?

DDX

Which conditions should be included in the differential diagnoses of mastocytosis?

What are the differential diagnoses for Mastocytosis?

Workup

How is mastocytosis diagnosed?

What is the role of lab tests in the workup of mastocytosis?

What are the WHO diagnostic criteria for systemic mast cell disease?

What is the role of imaging in the workup of mastocytosis?

When is a GI workup indicated in the evaluation of mastocytosis?

When is mast cell mediator testing indicated in the workup of mastocytosis?

What does elevated serum tryptase levels indicate in the workup of mastocytosis?

What is the role of urinary N-methylhistamine (NMH) and N-methylimidazoleacetic acid levels in the diagnosis of mastocytosis?

What is the role of urinary prostaglandin D2 metabolite level in the diagnosis of mastocytosis?

What is the role of bone marrow biopsy in the workup of mastocytosis?

What precautions are needed when administering anesthetic for biopsy in the workup of mastocytosis?

Which histologic findings are characteristic of mastocytosis?

Treatment

What is the focus of treatment for mastocytosis?

What is the role of H1 and H2 antihistamines in the management of mastocytosis?

What is the role of aspirin in the management of mastocytosis?

What is the role of corticosteroids in the management of mastocytosis?

What is the role of oral psoralen plus UV-A (PUVA) therapy in the management of mastocytosis?

What are the treatment options for vascular collapse in patients with mastocytosis?

What are surgical issues faced by patients with mastocytosis?

What is the role of interferon-alfa in the treatment of mastocytosis?

What is the role of immune modulators in the treatment of mastocytosis?

What is the role of lasers in the treatment of mastocytosis?

When is emergency care indicated for mastocytosis?

What are "B" findings indicative of a high systemic mastocytosis burden in patients?

What are "C" findings indicative of aggressive disease in patients with mastocytosis?

Which dietary modifications are used in the treatment of mastocytosis?

Which activity modifications are advisable for patients with mastocytosis?

Medications

Which medications are used in the treatment of mastocytosis?

Which medications in the drug class Vasopressors are used in the treatment of Mastocytosis?

Which medications in the drug class Histamine H2 antagonists are used in the treatment of Mastocytosis?

Which medications in the drug class Mast cell stabilizers are used in the treatment of Mastocytosis?

Which medications in the drug class Antihistamines are used in the treatment of Mastocytosis?