Diagnostic Considerations

Also consider the following:

Dermal nevus (also see Nevus Anemicus, Nevus Araneus (Spider Nevus), Nevus Comedonicus, and Nevus Sebaceus)
Fibrofolliculoma
Folliculosebaceous hamartoma ^{[8, 9]}

Note that trichofolliculoma has been reported to mimic squamous cell carcinoma on visualization and dermoscopy.^[10]

In a 7-year-old female patient, nevus lipomatosus cutaneous superficialis was associated with trichofolliculoma.^[11]

Differential Diagnoses

Workup

Gokalp H, Gurer MA, Alan S. Trichofolliculoma: a rare variant of hair follicle hamartoma. Dermatol Online J. 2013 Aug 15. 19 (8):19264. [QxMD MEDLINE Link].
Kapoor AG, V S V, Mittal R. Trichofolliculoma of the Eyelid Margin: A Case Report and Review of Literature. Ophthalmic Plast Reconstr Surg. 2019 May/Jun. 35 (3):e74-e76. [QxMD MEDLINE Link].
Lee HY, Kim EK, Choi HS, Jeong J. Trichofolliculoma in the Auricle. Ear Nose Throat J. 2021 Feb 15. 145561321995599. [QxMD MEDLINE Link]. [Full Text].
Saleem MI, Tham T, Ponder B, Georgolios A. Trichofolliculoma of the external auditory canal: a case report and review of the literature. J Surg Case Rep. 2022 Apr. 2022 (4):rjac147. [QxMD MEDLINE Link]. [Full Text].
Abdou AG, Asaad NY. Sebaceous trichofolliculoma of the cheek in a 65-year-old man. Pol J Pathol. 2014 Oct. 65 (3):253-4. [QxMD MEDLINE Link].
Ishii N, Kawaguchi H, Takahashi K, Nakajima H. A case of congenital trichofolliculoma. J Dermatol. 1992 Mar. 19(3):195-6. [QxMD MEDLINE Link].
El-Komy MH, Abdelkader HA. Congenital trichofolliculoma: a very rare presentation. Dermatol Online J. 2020 Jul 15. 26 (7):[QxMD MEDLINE Link]. [Full Text].
Cole P, Kaufman Y, Dishop M, Hatef DA, Hollier L. Giant, congenital folliculosebaceous cystic hamartoma: a case against a pathogenetic relationship with trichofolliculoma. Am J Dermatopathol. 2008 Oct. 30(5):500-3. [QxMD MEDLINE Link].
Wu YH. Folliculosebaceous cystic hamartoma or trichofolliculoma? A spectrum of hamartomatous changes inducted by perifollicular stroma in the follicular epithelium. J Cutan Pathol. 2008 Sep. 35(9):843-8. [QxMD MEDLINE Link].
Abdelbary A, Shakshouk H. Trichofolliculoma Mimicking Squamous Cell Carcinoma. Dermatol Pract Concept. 2022 Feb. 12 (1):e2022026. [QxMD MEDLINE Link]. [Full Text].
Agarwal A, Gulati HK, Das JK. Nevus Lipomatosus Cutaneous Superficialis Associated with Trichofolliculoma: An Uncommon Duet of Rare Pathologies. Int J Trichology. 2020 May-Jun. 12 (3):132-134. [QxMD MEDLINE Link]. [Full Text].
Misago N, Kimura T, Toda S, Mori T, Narisawa Y. A revaluation of trichofolliculoma: the histopathological and immunohistochemical features. Am J Dermatopathol. 2010 Feb. 32(1):35-43. [QxMD MEDLINE Link].
Hartschuh W, Schulz T. Immunohistochemical investigation of the different developmental stages of trichofolliculoma with special reference to the Merkel cell. Am J Dermatopathol. 1999 Feb. 21(1):8-15. [QxMD MEDLINE Link].
Plewig G. Sebaceous trichofolliculoma. J Cutan Pathol. 1980 Dec. 7(6):394-403. [QxMD MEDLINE Link].
Tanimura S, Arita K, Iwao F, et al. Two cases of folliculosebaceous cystic hamartoma. Clin Exp Dermatol. 2006 Jan. 31(1):68-70. [QxMD MEDLINE Link].
Stern JB, Stout DA. Trichofolliculoma showing perineural invasion. Trichofolliculocarcinoma?. Arch Dermatol. 1979 Aug. 115(8):1003-4. [QxMD MEDLINE Link].
Karaarslan I, Oraloglu G, Yaman B. In vivo reflectance confocal microscopic findings in a case of trichofolliculoma. An Bras Dermatol. 2022 Mar-Apr. 97 (2):236-239. [QxMD MEDLINE Link]. [Full Text].
Gray HR, Helwig EB. Trichofolliculoma. Arch Dermatol. 1962. 86:99-105.
Kligman AM, Pinkus H. The histogenesis of nevoid tumors of the skin. The folliculoma--a hair-follicle tumor. Arch Dermatol. 1960 Jun. 81:922-30. [QxMD MEDLINE Link].
Pinkus H, Sutton RL Jr. Trichofolliculoma. Arch Dermatol. 1965 Jan. 91:46-9. [QxMD MEDLINE Link].

Media Gallery

Low-power view of trichofolliculoma with a primary follicle opening onto the skin surface.
Edge of the primary follicle with associated secondary and tertiary budding follicular structures.
Higher magnification of budding follicular structures.
Low-power view of a section of trichofolliculoma demonstrating budding follicular structures and associated stroma.
Higher magnification of budding follicular structures and associated stroma.
Low-power view of sebaceous trichofolliculoma demonstrating dilated, primary follicle; budding follicular structures; and numerous associated sebaceous lobules.
Higher magnification of central primary follicle and associated sebaceous lobules.
Clinical appearance of trichofolliculoma.

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Author

Michael S Howard, MD Dermatopathologist and Laboratory Director, Georgia Dermatopathology Associates

Disclosure: Nothing to disclose.

Specialty Editor Board

Richard P Vinson, MD Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Texas Medical Association, Association of Military Dermatologists, Texas Dermatological Society

Disclosure: Nothing to disclose.

Rosalie Elenitsas, MD Herman Beerman Professor of Dermatology, University of Pennsylvania School of Medicine; Director, Penn Cutaneous Pathology Services, Department of Dermatology, University of Pennsylvania Health System

Rosalie Elenitsas, MD is a member of the following medical societies: American Academy of Dermatology, American Medical Association, American Society of Dermatopathology, Pennsylvania Academy of Dermatology

Disclosure: Received royalty from Lippincott Williams Wilkins for textbook editor.

Chief Editor

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

James W Patterson, MD Professor of Pathology and Dermatology, Director of Dermatopathology, University of Virginia Medical Center

James W Patterson, MD is a member of the following medical societies: American Academy of Dermatology, American College of Physicians, American Society of Dermatopathology, Royal Society of Medicine, Society for Investigative Dermatology, United States and Canadian Academy of Pathology

Disclosure: Nothing to disclose.

Bruce R Smoller, MD Executive Vice President, United States and Canadian Academy of Pathology

Bruce R Smoller, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, American Society of Dermatopathology, Arkansas Medical Society

Disclosure: Nothing to disclose.

Trichofolliculoma Differential Diagnoses

Diagnostic Considerations

Differential Diagnoses

References

Tables

Contributor Information and Disclosures

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