Acrochordon Clinical Presentation

Updated: Oct 26, 2022
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Acrochordons are flesh-colored pedunculated lesions that tend to occur in areas of skin folds. A family history sometimes exists of acrochordons. These tumors are usually asymptomatic, and they do not become painful unless inflamed or irritated. Patients may complain of pruritus or discomfort when an acrochordon is snagged by jewelry or clothing.

Acrochordons may occur at unusual sites of the body. A huge acrochordon has been described on the penis. [23] A lymphedematous acrochordon of the glans penis unassociated with condom catheter use also has been described. [24] Another large one was noted on vaginal labia of a 27-year-old woman. [25] An acrochordon may be associated with vulval itching without the symptom being the result of fungal infection. [26] Endoscopy may reveal FEPs arising in a ureter. [27]

Multiple skin tags are often linked with type 2 diabetes mellitus and with obesity, prompting a study of 58 people with skin tags. It showed that people with skin tags had significantly higher serum cholesterol and lower density lipoprotein levels, but not serum leptin levels, when compared with a healthy control group lacking skin tags. [28]

Acrochordons show a statistically significant relationship with obesity. [29]

Acrochordons have been linked with the components of the metabolic syndrome, [30, 31, 32] representing a cutaneous sign for impaired carbohydrate or lipid metabolism, liver enzyme abnormalities, and hypertension. [33] One survey from 2016 linked acrochordons with elevated serum triglyceride, low-density lipoprotein, very-low density lipoprotein, and leptin levels. [34] It was suggested that people with multiple acrochordons should be encouraged to reduce their weight, stop smoking, and practice healthy dietary habits.