Desmoid Tumor Medication

Updated: Mar 13, 2018
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Medication

Medication Summary

The goals of pharmacotherapy are to induce remission, to prevent complications, and to reduce morbidity. [37] Local recurrences are frequent after surgery, particularly if margins are positive. Radiotherapy alone for gross disease or after a microscopically incomplete resection yields local control rates of approximately 75-80%.

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Antineoplastic agents

Class Summary

These agents inhibit cell growth and proliferation. Pharmacologic agents result in objective response rates of approximately 40-50%; the duration of response is variable.

Doxorubicin (Adriamycin, Rubex)

Doxorubicin inhibits topoisomerase II and produces free radicals, which may cause the destruction of DNA. The combination of these 2 events, in turn, can inhibit the growth of neoplastic cells.

Dacarbazine (DTIC-Dome)

Dacarbazine inhibits DNA, RNA, and protein synthesis. It inhibits cell replication throughout all phases of the cell cycle.

Carboplatin (Paraplatin)

Carboplatin is an analog of cisplatin. It has the same efficacy as cisplatin but with a better toxicity profile.

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