Desmoid Tumor Questions & Answers

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7. Inoue Y, Ishida H, Ueno H, Kobayashi H, Yamaguchi T, Konishi T, et al. The treatment of desmoid tumors associated with familial adenomatous polyposis: the results of a Japanese multicenter observational study. Surg Today. 2017 Mar 1. [QxMD MEDLINE Link].

8. Fiore M, Crago A, Gladdy R, Kasper B. The Landmark Series: Desmoid. Ann Surg Oncol. 2021 Mar. 28 (3):1682-1689. [QxMD MEDLINE Link].

9. Pawluś A, Szymańska K, Kaczorowski K, Sokołowska-Dąbek D, Olchowy C, Markiewicz BD, et al. A Rare Case of Aggressive Fibromatosis Infiltrating Dorsal Muscles in a 6-Year-Old Patient - CT, MRI and Elastography Evaluation. Pol J Radiol. 2015. 80:164-7. [QxMD MEDLINE Link].

10. Wu C, Amini-Nik S, Nadesan P, Stanford WL, Alman BA. Aggressive fibromatosis (desmoid tumor) is derived from mesenchymal progenitor cells. Cancer Res. 2010 Oct 1. 70(19):7690-8. [QxMD MEDLINE Link].

11. Brueckl WM, Ballhausen WG, Fortsch T, et al. Genetic testing for germline mutations of the APC gene in patients with apparently sporadic desmoid tumors but a family history of colorectal carcinoma. Dis Colon Rectum. 2005 Jun. 48(6):1275-81. [QxMD MEDLINE Link].

12. Sturt NJ, Gallagher MC, Bassett P, et al. Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation. Gut. 2004 Dec. 53(12):1832-6. [QxMD MEDLINE Link].

13. Caspari R, Olschwang S, Friedl W, et al. Familial adenomatous polyposis: desmoid tumours and lack of ophthalmic lesions (CHRPE) associated with APC mutations beyond codon 1444. Hum Mol Genet. 1995 Mar. 4(3):337-40. [QxMD MEDLINE Link].

14. Cavallini A, Rotelli MT, Lippolis C, Piscitelli D, Digennaro R, Covelli C, et al. Human microRNA expression in sporadic and FAP-associated desmoid tumors and correlation with beta-catenin mutations. Oncotarget. 2017 Mar 19. [QxMD MEDLINE Link].

15. Wang WL, Nero C, Pappo A, Dina Lev DL, Lazar AJ, Lopez-Terrada DH. CTNNB1 Genotyping and APC Screening in Pediatric Desmoid Tumors: A Proposed Alogrithm. Pediatr Dev Pathol. 2012 Feb 28. [QxMD MEDLINE Link].

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17. Desmoid Tumor Working Group. The management of desmoid tumours: A joint global consensus-based guideline approach for adult and paediatric patients. Eur J Cancer. 2020 Mar. 127:96-107. [QxMD MEDLINE Link].

18. Gurbuz AK, Giardiello FM, Petersen GM, et al. Desmoid tumours in familial adenomatous polyposis. Gut. 1994 Mar. 35(3):377-81. [QxMD MEDLINE Link].

19. Lotfi AM, Dozois RR, Gordon H, et al. Mesenteric fibromatosis complicating familial adenomatous polyposis: predisposing factors and results of treatment. Int J Colorectal Dis. 1989. 4(1):30-6. [QxMD MEDLINE Link].

20. Wilcken N, Tattersall MH. Endocrine therapy for desmoid tumors. Cancer. 1991 Sep 15. 68(6):1384-8. [QxMD MEDLINE Link].

21. Waddell WR. Treatment of intra-abdominal and abdominal wall desmoid tumors with drugs that affect the metabolism of cyclic 3',5'-adenosine monophosphate. Ann Surg. 1975 Mar. 181(3):299-302. [QxMD MEDLINE Link].

22. Dhingra K. Antiestrogens--tamoxifen, SERMs and beyond. Invest New Drugs. 1999. 17(3):285-311. [QxMD MEDLINE Link].

23. Shields CJ, Winter DC, Kirwan WO, Redmond HP. Desmoid tumours. Eur J Surg Oncol. 2001 Dec. 27(8):701-6. [QxMD MEDLINE Link].

24. Klemmer S, Pascoe L, DeCosse J. Occurrence of desmoids in patients with familial adenomatous polyposis of the colon. Am J Med Genet. 1987 Oct. 28(2):385-92. [QxMD MEDLINE Link].

25. Lee JC, Thomas JM, Phillips S, Fisher C, Moskovic E. Aggressive fibromatosis: MRI features with pathologic correlation. AJR Am J Roentgenol. 2006 Jan. 186(1):247-54. [QxMD MEDLINE Link].

26. Huang PW, Tzen CY. Prognostic factors in desmoid-type fibromatosis: a clinicopathological and immunohistochemical analysis of 46 cases. Pathology. 2010 Feb. 42(2):147-50. [QxMD MEDLINE Link].

27. Meazza C, Bisogno G, Gronchi A, Fiore M, Cecchetto G, Alaggio R, et al. Aggressive fibromatosis in children and adolescents: the Italian experience. Cancer. 2010 Jan 1. 116(1):233-40. [QxMD MEDLINE Link].

28. Dufresne A, Paturel M, Alberti L, Philippon H, Duc A, Decouvelaere AV, et al. Prediction of desmoid tumor progression using miRNA expression profiling. Cancer Sci. 2015 May. 106 (5):650-5. [QxMD MEDLINE Link].

29. Quintini C, Ward G, Shatnawei A, Xhaja X, Hashimoto K, Steiger E, et al. Mortality of intra-abdominal desmoid tumors in patients with familial adenomatous polyposis: a single center review of 154 patients. Ann Surg. 2012 Mar. 255(3):511-6. [QxMD MEDLINE Link].

30. Colombo C, Miceli R, Lazar AJ, Perrone F, Pollock RE, Le Cesne A, et al. CTNNB1 45F mutation is a molecular prognosticator of increased postoperative primary desmoid tumor recurrence: An independent, multicenter validation study. Cancer. 2013 Jul 31. [QxMD MEDLINE Link].

31. Agrawal PS, Jagtap SM, Mitra SR. Extra-abdominal desmoid tumour of the leg. Singapore Med J. 2008 Jan. 49(1):e6-7. [QxMD MEDLINE Link].

32. Macgill AA, Milione VR, Sullivan LG. Extra-abdominal desmoid fibromatosis in the foot: a case study. J Am Podiatr Med Assoc. 2011 Jan-Feb. 101(1):70-4. [QxMD MEDLINE Link].

33. Shi B, Zhu Y, Xu Z, Liu Y, Zheng B, Qi T. Aggressive fibromatosis in the urological system. Report of two adult patients and review of the literature. Urol Int. 2007. 78(1):93-6. [QxMD MEDLINE Link].

34. Kohno J, Sumiyoshi T, Tsutsumi N, Maeno A, Okubo K, Mitsumori K, et al. [Scrotal desmoid tumor in a patient with familial adenomatous polyposis]. Hinyokika Kiyo. 2015 Jan. 61 (1):27-31. [QxMD MEDLINE Link].

35. Neri HA, Villagra EJ, Alvarez AC, et al. Ethmoidal desmoid tumor in a pediatric patient. Otolaryngol Head Neck Surg. 2007 Jan. 136(1):137-8. [QxMD MEDLINE Link].

36. Muller M, Dessogne P, Baron M, Picquenot JM, Riopel C, Diologent B, et al. [Desmoid tumor of the breast in a 9 years old little girl.]. Ann Pathol. 2011 Feb. 31(1):41-45. [QxMD MEDLINE Link].

37. Pajares B, Galera I, Ribelles N, Polo M. Insidious mastalgia hiding a desmoid tumour of the breast. Clin Transl Oncol. 2010 Jan. 12(1):63-5. [QxMD MEDLINE Link].

38. Mekhail FG, Montgomery JR, Spicer PJ. Imaging findings of a biopsy-proven desmoid tumor of the axilla in a young female. Radiol Case Rep. 2022 Apr. 17 (4):1050-1053. [QxMD MEDLINE Link]. [Full Text].

39. Jakowski JD, Mayerson J, Wakely PE Jr. Fine-needle aspiration biopsy of the distal extremities: a study of 141 cases. Am J Clin Pathol. 2010 Feb. 133(2):224-31. [QxMD MEDLINE Link].

40. El-Haddad M, El-Sebaie M, Ahmad R, et al. Treatment of aggressive fibromatosis: the experience of a single institution. Clin Oncol (R Coll Radiol). 2009 Dec. 21(10):775-80. [QxMD MEDLINE Link].

41. Mendenhall WM, Zlotecki RA, Morris CG, Hochwald SN, Scarborough MT. Aggressive fibromatosis. Am J Clin Oncol. 2005 Apr. 28(2):211-5. [QxMD MEDLINE Link].

42. Bhama PK, Chugh R, Baker LH, Doherty GM. Gardner's syndrome in a 40-year-old woman: successful treatment of locally aggressive desmoid tumors with cytotoxic chemotherapy. World J Surg Oncol. 2006 Dec 17. 4:96. [QxMD MEDLINE Link].

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44. Knechtel G, Stoeger H, Szkandera J, Dorr K, Beham A, Samonigg H. Desmoid tumor treated with polychemotherapy followed by imatinib: a case report and review of the literature. Case Rep Oncol. 2010 Aug 6. 3(2):287-93. [QxMD MEDLINE Link].

45. Colombo C, Foo WC, Whiting D, Young ED, Lusby K, Pollock RE, et al. FAP-related desmoid tumors: a series of 44 patients evaluated in a cancer referral center. Histol Histopathol. 2012 May. 27(5):641-9. [QxMD MEDLINE Link].

46. Ghanouni P, Dobrotwir A, Bazzocchi A, Bucknor M, Bitton R, Rosenberg J, et al. Magnetic resonance-guided focused ultrasound treatment of extra-abdominal desmoid tumors: a retrospective multicenter study. Eur Radiol. 2016 May 5. [QxMD MEDLINE Link].

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48. Sparber-Sauer M, Seitz G, von Kalle T, Vokuhl C, Leuschner I, Scheer M, et al. Systemic therapy of aggressive fibromatosis in children and adolescents: Report of the Cooperative Weichteilsarkom Studiengruppe (CWS). Pediatr Blood Cancer. 2018 Jan 5. [QxMD MEDLINE Link].

49. Mercier KA, Al-Jazrawe M, Poon R, Acuff Z, Alman B. A Metabolomics Pilot Study on Desmoid Tumors and Novel Drug Candidates. Sci Rep. 2018 Jan 12. 8 (1):584. [QxMD MEDLINE Link].

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Robert A Schwartz, MD, MPH Professor and Head of Dermatology, Professor of Pathology, Professor of Pediatrics, Professor of Medicine, Rutgers New Jersey Medical School

Robert A Schwartz, MD, MPH is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, New York Academy of Medicine, Royal College of Physicians of Edinburgh, Sigma Xi, The Scientific Research Honor Society

Disclosure: Nothing to disclose.

Peter C Lambert, MS St George's University School of Medicine, Grenada

Disclosure: Nothing to disclose.

David F Butler, MD Former Section Chief of Dermatology, Central Texas Veterans Healthcare System; Professor of Dermatology, Texas A&M University College of Medicine; Founding Chair, Department of Dermatology, Scott and White Clinic

David F Butler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, Association of Military Dermatologists, Phi Beta Kappa, Texas Dermatological Society

Disclosure: Nothing to disclose.

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Neil Shear, MD Professor and Chief of Dermatology, Professor of Medicine, Pediatrics and Pharmacology, University of Toronto Faculty of Medicine; Head of Dermatology, Sunnybrook Women's College Health Sciences Center and Women's College Hospital, Canada

Neil Shear, MD is a member of the following medical societies: Canadian Medical Association, Ontario Medical Association, Royal College of Physicians and Surgeons of Canada, Canadian Dermatology Association, American Academy of Dermatology, American Society for Clinical Pharmacology and Therapeutics

Disclosure: Nothing to disclose.

Matthew J Trovato, MD Fellow, Division of Plastic Surgery, Rutgers New Jersey Medical School

Disclosure: Nothing to disclose.

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