Verruciform Xanthoma Treatment & Management

Updated: Nov 07, 2019
  • Author: W Clark Lambert, MD, PhD; Chief Editor: William D James, MD  more...
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Approach Considerations

No management guidelines for verruciform xanthoma exist. [40] Local surgical excision is almost always curative for verruciform xanthoma. Recurrence is rare, with only a few cases reported; recurrences may be adequately treated with a second local excision. In some cases, surgical excision can be traumatic and deforming.

A 2-year-old girl with multiple verruciform xanthoma lesions around her anus and vulva was treated with 5% imiquimod on the lesions twice per week. After 4 months, the lesions  appeared to be almost entirely cleared, with no obvious adverse effects.

Cryotherapy, electrosection, pulsed dye laser, and radiation therapy have all failed as reliable therapeutic modalities. [95]