Bullous Disease of Diabetes (Bullosis Diabeticorum) Questions & Answers

1. Kurdi AT. Bullosis diabeticorum. Lancet. 2013 Nov 30. 382(9907):e31. [QxMD MEDLINE Link]. [Full Text].

2. Bustan RS, Wasim D, Yderstræde KB, Bygum A. Specific skin signs as a cutaneous marker of diabetes mellitus and the prediabetic state - a systematic review. Dan Med J. 2017 Jan. 64(1):[QxMD MEDLINE Link]. [Full Text].

3. Taylor SP, Dunn K. Bullosis diabeticorum. J Gen Intern Med. 2017 Feb. 32(2):220. [QxMD MEDLINE Link]. [Full Text].

4. Brzezinski P, Chiriac AE, Pinteala T, Foia L, Chiriac A. Diabetic dermopathy ("shin spots") and diabetic bullae ("bullosis diabeticorum") at the same patient. Pak J Med Sci. 2015 Sep-Oct. 31(5):1275-6. [QxMD MEDLINE Link]. [Full Text].

5. Michael MJ, Mefford JM, Lahham S, Chandwani CE. Bullosis diabeticorum. West J Emerg Med. 2016 Mar. 17(2):188. [QxMD MEDLINE Link]. [Full Text].

6. Kramer DW. Early or warning signs of impending gangrene in diabetes. Med J Rec. 1930. 132:338-42.

7. Rocca FF, Pereyra E. Phlyctenar lesions in the feet of diabetic patients. Diabetes. 1963 May-Jun. 12:220-2. [QxMD MEDLINE Link]. [Full Text].

8. Cantwell AR Jr, Martz W. Idiopathic bullae in diabetics. Bullosis diabeticorum. Arch Dermatol. 1967 Jul. 96(1):42-4. [QxMD MEDLINE Link].

9. Zhang AJ, Garret M, Miller S. Bullosis diabeticorum: case report and review. N Z Med J. 2013 Mar 15. 126(1371):91-4. [QxMD MEDLINE Link].

10. Vangipuram R, Hinojosa T, Lewis DJ, et al. Bullosis diabeticorum: a neglected bullous dermatosis. Skinmed. 2018. 16(1):77-9. [QxMD MEDLINE Link].

11. Sonani H, Abdul Salim S, Garla VV, Wile A, Palabindala V. Bullosis diabeticorum: a rare presentation with immunoglobulin G (IgG) deposition related vasculopathy. Case report and focused review. Am J Case Rep. 2018 Jan 15. 19:52-6. [QxMD MEDLINE Link]. [Full Text].

12. Bernstein JE, Levine LE, Medenica MM, Yung CW, Soltani K. Reduced threshold to suction-induced blister formation in insulin-dependent diabetics. J Am Acad Dermatol. 1983 Jun. 8(6):790-1. [QxMD MEDLINE Link].

13. Larsen K, Jensen T, Karlsmark T, Holstein PE. Incidence of bullosis diabeticorum--a controversial cause of chronic foot ulceration. Int Wound J. 2008 Oct. 5(4):591-6. [QxMD MEDLINE Link].

14. Wilson TC, Snyder RJ, Southerland CC. Bullosis diabeticorum: is there a correlation between hyperglycemia and this symptomatology?. Wounds. 2012 Dec. 24(12):350-5. [QxMD MEDLINE Link].

15. Toonstra J. Bullosis diabeticorum. Report of a case with a review of the literature. J Am Acad Dermatol. 1985 Nov. 13(5 Pt 1):799-805. [QxMD MEDLINE Link].

16. James WD, Odom RB, Goette DK. Bullous eruption of diabetes mellitus. A case with positive immunofluorescence microscopy findings. Arch Dermatol. 1980 Oct. 116(10):1191-2. [QxMD MEDLINE Link].

17. Lopez PR, Leicht S, Sigmon JR, Stigall L. Bullosis diabeticorum associated with a prediabetic state. South Med J. 2009 Jun. 102(6):643-4. [QxMD MEDLINE Link].

18. Chiriac A, Costache I, Podoleanu C, Naznean A, Stolnicu S. Bullosis diabeticorum in a young child: case report of a very rare entity and a literature review. Can J Diabetes. 2017 Apr. 41(2):129-31. [QxMD MEDLINE Link].

19. Tunuguntla A, Patel KN, Peiris AN, Zakaria WN. Bullosis diabeticorum associated with osteomyelitis. Tenn Med. 2004 Nov. 97(11):503-4. [QxMD MEDLINE Link].

20. Lipsky BA, Baker PD, Ahroni JH. Diabetic bullae: 12 cases of a purportedly rare cutaneous disorder. Int J Dermatol. 2000 Mar. 39(3):196-200. [QxMD MEDLINE Link].

21. Gupta V, Gulati N, Bahl J, Bajwa J, Dhawan N. Bullosis diabeticorum: rare presentation in a common disease. Case Rep Endocrinol. 2014. 2014:862912. [QxMD MEDLINE Link]. [Full Text].

22. Basarab T, Munn SE, McGrath J, Russell Jones R. Bullosis diabeticorum. A case report and literature review. Clin Exp Dermatol. 1995 May. 20(3):218-20. [QxMD MEDLINE Link].

23. Chen Y, Ma Y, Li N, et al. Efficacy and long-term longitudinal follow-up of bone marrow mesenchymal cell transplantation therapy in a diabetic patient with recurrent lower limb bullosis diabeticorum. Stem Cell Res Ther. 2018 Apr 10. 9(1):99. [QxMD MEDLINE Link]. [Full Text].

24. [Guideline] American Diabetes Association. 11. Microvascular complications and foot care: Standards of Medical Care in Diabetes-2019. Diabetes Care. 2019 Jan. 42(Suppl 1):S124-38. [QxMD MEDLINE Link]. [Full Text].

25. Byrd V, Nemeth A. Steroid-induced diabetes complicating treatment of epidermolysis bullosa acquisita: a preventable treatment complication stresses the importance of primary care follow-up. Cureus. 2018 Nov 19. 10(11):e3608. [QxMD MEDLINE Link]. [Full Text].

Sofia Junaid Syed, MD, MPH Medical Director of Diabetes Network, Director of Thyroid Clinic, Assistant Division Chief of Endocrinology, Bassett Healthcare Network; Adjunct Assistant Clinical Professor of Medicine, Columbia University College of Physicians and Surgeons

Sofia Junaid Syed, MD, MPH is a member of the following medical societies: American Association of Clinical Endocrinologists, American College of Physicians, American Medical Association, American Society of Hypertension, Endocrine Society

Disclosure: Nothing to disclose.

Panadeekarn (Natty) Panjawatanan, MD Resident Physician, Department of Internal Medicine, Bassett Medical Center

Panadeekarn (Natty) Panjawatanan, MD is a member of the following medical societies: Royal College of Physicians of Thailand

Disclosure: Nothing to disclose.

Vijaykumar Sekar, MD, MBBS Resident Physician, Department of Internal Medicine, Bassett Medical Center

Vijaykumar Sekar, MD, MBBS is a member of the following medical societies: American College of Physicians, American Medical Association, British Medical Association, Indian Medical Association, Royal College of Physicians and Surgeons of the United Kingdom

Disclosure: Nothing to disclose.

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Jacqueline M Junkins-Hopkins, MD Associate Professor, Director, Division of Dermatopathology and Oral Pathology, Department of Dermatology, Johns Hopkins Medical Institutions

Jacqueline M Junkins-Hopkins, MD is a member of the following medical societies: American Academy of Dermatology, American College of Physicians, American Society of Dermatopathology

Disclosure: Nothing to disclose.

Edward F Chan, MD Clinical Assistant Professor, Department of Dermatology, University of Pennsylvania School of Medicine

Edward F Chan, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, and Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Michael J Wells, MD Associate Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine

Michael J Wells, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, and Texas Medical Association

Disclosure: Nothing to disclose.

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