Drug-Induced Bullous Disorders Differential Diagnoses

Updated: Apr 30, 2018
  • Author: David F Butler, MD; Chief Editor: William D James, MD  more...
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DDx

Diagnostic Considerations

Consider the following:

  • Eczematous drug eruption - Allergic or irritant contact dermatitis, intradermal reactions, photoallergic reactions, nummular dermatitis, atopic dermatitis
  • AGEP - Impetigo, staphylococcal scalded skin syndrome, pustular psoriasis, Reiter disease, subcorneal pustular dermatosis, pemphigus foliaceus, candidiasis, pustular dermatophyte infection
  • FDE - Erythema chronicum migrans, SJS-TEN, bullous disease of diabetes mellitus, bullous disease of dialysis, bullous reactions with drug overdose/coma and bullous phototoxic contact reactions to plants, postinflammatory hyperpigmentation, factitial dermatitis
  • EM - Paraneoplastic pemphigus, other autoimmune blistering diseases, lupus erythematosus, bullous lichen planus, urticaria, FDE
  • Drug-induced pemphigus - Pemphigus vulgaris, pemphigus foliaceus, pemphigus vegetans, bullous pemphigoid, dermatitis herpetiformis, PCT, TEN, EM, bullous contact dermatitis
  • Drug-induced pemphigoid - Reflex sympathetic dystrophy, linear IgA bullous dermatosis, bullous disease of diabetes mellitus, EM, bullous systemic lupus erythematosus, dermatitis herpetiformis, burn, epidermolysis bullosa, leukocytoclastic vasculitis, chronic actinic dermatitis, and cicatricial pemphigoid
  • Drug-induced LAD - Non–drug-induced LAD, dermatitis herpetiformis, bullous pemphigoid, cicatricial pemphigoid, EM
  • Pseudoporphyria - True PCT, bullous pemphigoid, epidermolysis bullosa acquisita, photoallergic dermatitis, allergic contact dermatitis

Differential Diagnoses