Fogo Selvagem Medication

Updated: Apr 16, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
  • Print
Medication

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and prevent complications.

Next:

Corticosteroids

Class Summary

These agents have anti-inflammatory properties and cause profound and varied metabolic effects. They modify the body's immune response to diverse stimuli. Corticosteroids are used to treat inflammatory dermatosis responsive to steroids. They decrease inflammation by suppressing the migration of polymorphonuclear leukocytes and reversing capillary permeability.

Prednisone (Deltasone, Meticorten, Orasone)

Prednisone is a synthetic adrenocortical steroid with predominantly glucocorticoid properties. It may decrease inflammation by reversing increased capillary permeability and suppressing neutrophil activity.

Clobetasol (Temovate)

Clobetasol is a class I superpotent topical steroid. It suppresses mitosis and increases synthesis of proteins that decrease inflammation and cause vasoconstriction.

Previous
Next:

Immunosuppressives

Class Summary

These agents inhibit key factors in the immune system responsible for inflammatory reactions.

Azathioprine (Imuran)

Azathioprine antagonizes purine metabolism and inhibits synthesis of DNA, RNA, and proteins. It may decrease the proliferation of immune cells, resulting in lower autoimmune activity.

Cyclophosphamide (Cytoxan, Neosar)

Cyclophosphamide is an immunosuppressive agent. It may be used as monotherapy or as a steroid-sparing agent. Cyclophosphamide is chemically related to nitrogen mustards. As an alkylating agent, its mechanism of action of active metabolites may involve cross-linking of DNA, which may interfere with growth of normal and neoplastic cells.

Mycophenolate mofetil (CellCept)

Mycophenolate mofetil inhibits inosine monophosphate dehydrogenase (IMPDH) and suppresses de novo purine synthesis by lymphocytes, thereby inhibiting their proliferation. It inhibits antibody production.

Previous
Next:

Antibiotics

Class Summary

Antimicrobial agents with anti-inflammatory effects may be used.

Tetracycline (Sumycin, Achromycin)

Tetracycline has anti-inflammatory activity. Use it in combination therapy with nicotinamide.

Previous
Next:

Anti-inflammatories

Class Summary

Dapsone is bactericidal and bacteriostatic against mycobacteria. The mechanism of action is similar to that of sulfonamides in which competitive antagonists of PABA prevent the formation of folic acid, inhibiting bacterial growth.

Dapsone (Avlosulfon)

Dapsone is used to control dermatologic symptoms of dermatitis herpetiformis. It can be used for patients with pemphigus, and it may be the drug of choice for pemphigus herpetiformis and IgA pemphigus. Dapsone may be provided as monotherapy or in combination with systemic steroids and immunosuppressants.

Previous
Next:

Vitamins

Class Summary

Vitamins are essential for DNA synthesis and metabolism of proteins, carbohydrates, and fats, and for normal growth and development.

Niacin (Vitamin B-3, Niacinamide)

This is the source of niacin used in tissue respiration, lipid metabolism, and glycogenolysis. Use it in combination therapy with tetracycline.

Previous