IgA Pemphigus Medication

Updated: Apr 18, 2017
  • Author: Blanca Anais Estupiñan; Chief Editor: Dirk M Elston, MD  more...
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Medication

Medication Summary

In general, corticosteroids are the mainstay of treatment for IgA pemphigus. Dapsone, a medication with antineutrophilic effects, also may be helpful. Anti-inflammatory agents theoretically block the inflammatory process and improve the disease conditions. [33, 35]

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Anti-inflammatory agents

Class Summary

IgA pemphigus is characterized histologically by inflammatory cell (neutrophil) infiltration in the upper epidermis. Anti-inflammatory agents theoretically block the inflammatory process and improve the disease conditions.

Prednisone (Deltasone)

Prednisone is an effective treatment for IgA pemphigus. It is an immunosuppressant for the treatment of autoimmune disorders; it may decrease inflammation by reversing increased capillary permeability and suppressing PMN activity. Prednisone stabilizes lysosomal membranes and suppresses lymphocytes and antibody production. Consult a pediatrician before prescribing this medication in children.

Dapsone (Avlosulfon)

Dapsone is bactericidal and bacteriostatic against mycobacteria; its mechanism of action is similar to sulfonamides, in which competitive antagonists of PABA prevent formation of folic acid, inhibiting bacterial growth. Dapsone is used alone or in conjunction with other anti-inflammatory medications for treating IgA pemphigus. Consult a pediatrician before prescribing medication in children.

Acitretin (Soriatane)

Acitretin is a retinoic acid analog. Its mechanism of action is unknown. Acitretin has been used effectively in several reported cases of IgA pemphigus.

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