Pemphigus Vulgaris Questions & Answers

Updated: Sep 17, 2020
  • Author: Bassam Zeina, MD, PhD; Chief Editor: Dirk M Elston, MD  more...
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Questions & Answers

Overview

What is pemphigus vulgaris?

What are the signs and symptoms of pemphigus vulgaris in the oral cavity?

What are the signs and symptoms of pemphigus vulgaris on the skin?

What are the signs and symptoms of pemphigus vulgaris on nails?

What are the signs and symptoms of vegetating pemphigus vulgaris?

Which lab studies are performed in the workup of pemphigus vulgaris?

What is the role of pharmacologic therapy for pemphigus vulgaris?

What is pemphigus vulgaris?

What is the pathophysiology of pemphigus vulgaris?

What is the role of antigens in the pathogenesis of pemphigus vulgaris?

What is the role of antibodies in the pathogenesis of pemphigus vulgaris?

What is the role of complements in the pathogenesis of pemphigus vulgaris?

What is the prevalence of pemphigus vulgaris in the US?

What is the global incidence of pemphigus vulgaris?

What are the racial predilections of pemphigus vulgaris?

How does the incidence of pemphigus vulgaris vary by sex?

How does the incidence of pemphigus vulgaris vary by age?

What is the mortality rate of pemphigus vulgaris?

What is an alternative to serial skin biopsies for obtaining immunofluorescence specimens of pemphigus vulgaris?

What is the prognosis of pemphigus vulgaris?

What is included in patient education about pemphigus vulgaris?

Presentation

What is the prevalence of oral lesions in pemphigus vulgaris?

How are skin lesions characterized in pemphigus vulgaris?

Which drugs may induce pemphigus vulgaris?

What is the initial physical finding of pemphigus vulgaris?

What are the characteristic mucosal findings of pemphigus vulgaris?

What are the cutaneous findings of pemphigus vulgaris?

What are the physical findings characteristic of vegetating pemphigus vulgaris?

What are the physical findings on nails characteristic of pemphigus vulgaris?

What are the physical findings characteristic of pemphigus vulgaris during pregnancy?

What are the Nikolsky sign and Asboe-Hansen sign in pemphigus vulgaris?

What causes pemphigus vulgaris?

What is the role of genetics in the etiology of pemphigus vulgaris?

Which age groups are at highest risk for pemphigus vulgaris?

What disorders are associated with pemphigus vulgaris?

DDX

What are the differential diagnoses for Pemphigus Vulgaris?

Workup

What is the role of indirect immunofluorescence (IDIF) in the workup of pemphigus vulgaris?

What is the role of lab testing in the diagnosis of pemphigus vulgaris?

What is the role of direct immunofluorescence (DIF) in the workup of pemphigus vulgaris?

What are the histologic features of pemphigus vulgaris?

Treatment

What are the goals of treatment for pemphigus vulgaris?

Which drugs are used in the treatment of pemphigus vulgaris?

Which specialist consultations may be needed for the treatment of pemphigus vulgaris?

Which dietary modifications are used in the treatment of pemphigus vulgaris?

Which activity modifications are used in the treatment of pemphigus vulgaris?

What are potential complications of pemphigus vulgaris?

Medications

What are the goals of treatment for pemphigus vulgaris?

What is the efficacy of drug treatment for pemphigus vulgaris?

What is the role of cyclophosphamide in the treatment of pemphigus vulgaris?

Which medications in the drug class Immunosuppressive agents are used in the treatment of Pemphigus Vulgaris?

Which medications in the drug class Anti-inflammatory agents are used in the treatment of Pemphigus Vulgaris?

Which medications in the drug class Anti-CD20 Monoclonal Antibodies are used in the treatment of Pemphigus Vulgaris?