CREST Syndrome Differential Diagnoses

Updated: Oct 05, 2020
  • Author: Jeanie C Yoon, MD; Chief Editor: Dirk M Elston, MD  more...
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DDx

Diagnostic Considerations

Consider the following:

  • Sclerodermalike disorders
  • Diffuse scleroderma
  • Limited scleroderma
  • Morphea
  • Mixed connective-tissue disease
  • Vinyl chloride disease
  • Silica exposure
  • Amyloidosis
  • Eosinophilic fasciitis
  • Eosinophilia-myalgia syndrome
  • Toxic oil syndrome
  • Type 1 diabetes mellitus
  • Carcinoid syndrome
  • Myeloma
  • Paraproteinemia
  • Scleromyxedema
  • Chronic graft versus host disease
  • POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes)
  • Porphyria cutanea tarda
  • Phenylketonuria
  • Raynaud phenomenon
  • Primary Raynaud phenomenon
  • Secondary Raynaud phenomenon
  • Livedo reticularis
  • Acrocyanosis
  • Diffuse systemic sclerosis
  • Limited systemic sclerosis
  • Systemic lupus erythematosus
  • Dermatomyositis
  • Rheumatoid arthritis
  • Sjögren syndrome
  • Systemic vasculitis
  • Cryoglobulinemia
  • Macroglobulinemia
  • Cold agglutinins
  • Beta-adrenergic blockers
  • Nicotine
  • Ergotamine
  • Vinyl chloride exposure
  • Thoracic outlet syndrome
  • Atherosclerotic disease
  • Thromboangiitis obliterans (Buerger disease)
  • Frostbite
  • Vibratory tool use
  • Reflex sympathetic dystrophy
  • Carpal tunnel syndrome
  • Diabetes mellitus
  • Calcinosis
  • Dystrophic calcinosis (normal calcium/phosphorus)
  • Dermatomyositis
  • Systemic lupus erythematosus
  • Scleroderma
  • Panniculitis
  • Porphyria cutanea tarda
  • Ehlers-Danlos syndrome
  • Pseudoxanthoma elasticum
  • Werner syndrome
  • Cutaneous neoplasms
  • Infections
  • Trauma
  • Metastatic calcinosis
  • Chronic renal failure
  • Hypervitaminosis D
  • Milk-alkali syndrome
  • Neoplasms
  • Sarcoidosis
  • Pseudoxanthoma elasticum
  • Calciphylaxis
  • Idiopathic calcinosis
  • Tumoral calcinosis
  • Subepidermal calcified nodule
  • Idiopathic calcinosis cutis in Down syndrome
  • Idiopathic calcification of the scrotum
  • Iatrogenic calcinosis
  • Primary telangiectasia
  • Ataxia telangiectasia
  • Generalized essential telangiectasia
  • Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome)
  • Spider angiomas
  • Unilateral nevoid telangiectasia syndrome
  • Secondary telangiectasia
  • Actinically damaged skin
  • Postlaser or electrosurgery
  • Postcryosurgery
  • Basal cell carcinoma
  • Collagen-vascular disease
  • Dermatomyositis
  • Lupus erythematosus
  • Scleroderma
  • Cushing syndrome
  • Estrogen excess
  • Cirrhosis
  • Oral contraceptives
  • Pregnancy
  • Poikiloderma
  • Metastatic carcinoma
  • Necrobiosis lipoidica diabeticorum
  • Pseudoxanthoma elasticum
  • Radiation therapy injury
  • Rosacea
  • Generalized cutaneous mastocytosis
  • Topical steroid induced
  • Xeroderma pigmentosa