Drug-Induced Lupus Erythematosus Questions & Answers

Updated: Jul 10, 2018
  • Author: Catharine Lisa Kauffman, MD, FACP; Chief Editor: Dirk M Elston, MD  more...
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Questions & Answers

Overview

What is drug-induced lupus erythematosus (DILE)?

How is drug-induced lupus erythematosus (DILE) differentiated from systemic lupus erythematosus (SLE)?

How is drug-induced lupus erythematosus (DILE) treated?

What is the role of anti–TNF-α agents in the pathophysiology of drug-induced lupus erythematosus (DILE)?

What is the pathophysiology of drug-induced lupus erythematosus (DILE)?

What are predisposing factors to the development of drug-induced lupus erythematosus (DILE)?

What is the prevalence of drug-induced lupus erythematosus (DILE) in patients taking anti–TNF-α agents?

What are the signs and symptoms of drug-induced lupus erythematosus (DILE) in patients taking anti–TNF-α agents?

What causes drug-induced lupus erythematosus (DILE)?

Which medications may cause drug-induced lupus erythematosus (DILE)?

What is the role of genetics in the etiology of drug-induced lupus erythematosus (DILE)?

What are the non-medication causes of drug-induced lupus erythematosus (DILE)?

Which drugs cause flares of systemic lupus erythematosus (SLE)?

What is the prevalence of drug-induced lupus erythematosus (DILE)?

What is the prognosis of drug-induced lupus erythematosus (DILE)?

Presentation

Which clinical history findings are characteristic of drug-induced lupus erythematosus (DILE)?

Which physical findings are characteristic of drug-induced lupus erythematosus (DILE)?

Which physical findings help differentiate drug-induced lupus erythematosus (DILE) from systemic lupus erythematosus (SLE)?

Which physical findings are characteristic of drug-induced subacute cutaneous lupus erythematosus (DISCLE)?

What are the possible complications of drug-induced lupus erythematosus (DILE)?

DDX

How is drug-induced lupus erythematosus (DILE) diagnosed?

What are the differential diagnoses for Drug-Induced Lupus Erythematosus?

Workup

What is the role of antibody assays in the diagnosis of drug-induced lupus erythematosus (DILE)?

What is the role of lab testing in the diagnosis of drug-induced lupus erythematosus (DILE)?

What is the role of imaging studies in the diagnosis of drug-induced lupus erythematosus (DILE)?

What is the role of skin biopsy in the diagnosis of drug-induced lupus erythematosus (DILE)?

Which histologic findings are characteristic of drug-induced lupus erythematosus (DILE)?

Treatment

How is drug-induced lupus erythematosus (DILE) treated?

Medications

Which medications are used in the treatment of drug-induced lupus erythematosus (DILE)?

Which medications in the drug class Corticosteroids are used in the treatment of Drug-Induced Lupus Erythematosus?