Acute Cutaneous Lupus Erythematosus (ACLE) Differential Diagnoses

Updated: May 10, 2017
  • Author: Fnu Nutan, MD, FACP; Chief Editor: William D James, MD  more...
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Diagnostic Considerations

Dermatomyositis, one differential to consider in the diagnosis of acute cutaneous lupus erythematosus (ACLE), mimics lupus erythematosus clinically and histologically. However, antinuclear antibody (ANA) assay results invariably are positive in patients with systemic lupus erythematosus (SLE) and in those with ACLE, but they are less likely to be positive in those with dermatomyositis.

Acne rosacea should also be considered in the differential diagnosis of ACLE.

Differential Diagnoses