Dermatologic Manifestations of Mixed Connective Tissue Disease Differential Diagnoses

Updated: May 11, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
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DDx

Diagnostic Considerations

Also consider Kikuchi disease. [29]

Different connective-tissue diseases, especially early and particularly in childhood, may be challenging to diagnose. Months or years may pass before an accurate diagnosis can be made. [30] The 2013 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Systemic Sclerosis (SSc) on defined subgroups of systemic sclerosis (SSc) and in mixed connective-tissue disease (MCTD) as an SSc-related disease were found to be more sensitive than the American College of Rheumatology 1980 criteria. [31] However, there remain concerns with regard to distinguishing systemic sclerosis from MCTD.

Differential Diagnoses