Lentigo Medication

Updated: Mar 16, 2020
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: William D James, MD  more...
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Medication

Medication Summary

The goal of pharmacotherapy is to reduce morbidity and prevent complications.

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Retinoids

Class Summary

Retinoids decrease the cohesiveness of abnormal hyperproliferative keratinocytes and may reduce the potential for malignant degeneration. These agents modulate keratinocyte differentiation. They have been shown to reduce the risk of skin cancer in patients who have undergone renal transplantation.

Tretinoin 0.025 to 0.1% (Retin-A, Avita)

Tretinoin is a keratolytic agent. It acts by increasing epidermal cell mitosis and turnover while suppressing keratin synthesis. An important side effect of interest is hypopigmentation, which reduces the appearance of lentigines.

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Bleaching creams

Class Summary

These agents lighten hyperpigmented skin by inhibiting enzymatic oxidation of tyrosine and by suppressing other melanocyte metabolic processes, thereby further inhibiting melanin production.

Hydroquinone (Eldopaque-Forte, Solaquin Forte, Lustra)

Hydroquinone suppresses melanocyte metabolic processes, especially enzymatic oxidation of tyrosine to 3,4-dihydroxyphenylamine. Exposure to sun reverses the effects and causes repigmentation.

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