Argyria Medication

Updated: Sep 12, 2017
  • Author: Kamila K Padlewska, MD, PhD; Chief Editor: William D James, MD  more...
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Medication

Medication Summary

Selenium and sulfur have been shown to have favorable modifying effects on the metabolism and toxicity of silver by forming complexes with silver. Silver selenide is highly insoluble in vivo, and this effectively reduces the availability of monovalent silver to interfere with normal enzymatic activities in tissues. However, the silver-sulfur complexes formed in vivo do not seem as stable as silver-selenium complexes.

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Pigment agents

Class Summary

According to reports, a 4% hydroquinone treatment could reduce the number of silver granules in the upper dermis and around sweat glands and reduce the number of melanocytes; however, no completely satisfactory treatment modalities exist and some pigmentation remains permanently.

Hydroquinone (Eldopaque-Forte, Solaquin Forte, Lustra)

Topical application produces a reversible depigmentation of the skin by the inhibition of the enzymatic oxidation of tyrosine to 3,4-dihydroxyphenylalanine and suppression of the melanocyte metabolic process.

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