Griscelli Syndrome Questions & Answers

Updated: Jan 14, 2020
  • Author: Saud A Alobaida, MBBS, FRCPC; Chief Editor: Dirk M Elston, MD  more...
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Questions & Answers

Overview

What is Griscelli syndrome (GS)?

What is the role of genetics in the pathogenesis of Griscelli syndrome (GS)?

What causes Griscelli syndrome (GS)?

What is the US prevalence of Griscelli syndrome (GS)?

What is the global prevalence of Griscelli syndrome (GS)?

What is the racial predilection of Griscelli syndrome (GS)?

What is the sexual predilection of Griscelli syndrome (GS)?

What is the typical age of onset for Griscelli syndrome (GS)?

What is the prognosis for Griscelli syndrome (GS)?

What is included in patient education about Griscelli syndrome (GS)?

Presentation

Which clinical history findings are characteristic of Griscelli syndrome (GS)?

Which clinical history findings are characteristic of Griscelli syndrome (GS) type 1?

Which clinical history findings are characteristic of Griscelli syndrome (GS) type 2?

Which clinical history findings are characteristic of Griscelli syndrome (GS) type 3?

Which physical exam findings are characteristic of Griscelli syndrome (GS)?

What are the possible complications of Griscelli syndrome (GS) type 1?

What are the possible complications of Griscelli syndrome (GS) type 2?

DDX

Which conditions are included in the differential diagnoses of Griscelli syndrome (GS)?

What are the differential diagnoses for Griscelli Syndrome?

Workup

What is the role of lab tests in the workup for Griscelli syndrome (GS)?

What is the role of imaging studies in the workup for Griscelli syndrome (GS)?

Which transmission electron microscopy findings are characteristic of Griscelli syndrome (GS)?

How is Griscelli syndrome (GS) differentiated from Chédiak-Higashi syndrome (CHS)?

What is the role of biopsy in the workup of Griscelli syndrome (GS)?

What is the role of bone marrow aspiration in the workup of Griscelli syndrome (GS)?

Which histologic findings are characteristic of Griscelli syndrome (GS)?

Treatment

How is Griscelli syndrome (GS) treated?

How is Griscelli syndrome (GS) type 1 treated?

How is Griscelli syndrome (GS) type 2 treated?

What is the role of surgery in the treatment of Griscelli syndrome (GS)?

Which specialist consultations are beneficial to patients with Griscelli syndrome (GS)?

Which dietary modifications are used in the treatment of Griscelli syndrome (GS)?

Which activity modifications are used in the treatment of Griscelli syndrome (GS)?

How is Griscelli syndrome (GS) diagnosed prenatally?

What type of long-term monitoring is needed for patients with Griscelli syndrome (GS)?

Medications

What is the role of medications in the treatment of Griscelli syndrome (GS)?

Which medications in the drug class Antimetabolites are used in the treatment of Griscelli Syndrome?

Which medications in the drug class Antineoplastics are used in the treatment of Griscelli Syndrome?

Which medications in the drug class Immunosuppressive Antibodies are used in the treatment of Griscelli Syndrome?

Which medications in the drug class Immunosuppressants are used in the treatment of Griscelli Syndrome?