Fox-Fordyce Disease Clinical Presentation

Updated: Jun 15, 2022
  • Author: Christopher R Gorman, MD; Chief Editor: William D James, MD  more...
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Physical Examination

The apocrine glands are the site of Fox-Fordyce disease. Lesions are most often found in the axillae, where they tend to be bilateral. Lesions may also affect the periareolar, inframammary, and pubic areas.

The primary lesion is a flesh-colored to reddish, smooth, dome-shaped, discrete, and follicular or perifollicular papule. Affected areas usually have many papules. The papules usually appear to affect every follicle in a given area. Excoriations and lichenification may be seen as a consequence of scratching.

Sweating is often absent in the affected area.