Neutrophilic Eccrine Hidradenitis Medication

Updated: Aug 27, 2019
  • Author: Joseph C Pierson, MD; Chief Editor: Dirk M Elston, MD  more...
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Medication

Medication Summary

Pain relief is sometimes necessary in neutrophilic eccrine hidradenitis (NEH). Nonsteroidal anti-inflammatory drugs (NSAIDs) appear to be the simplest intervention and decrease associated fever. Systemic corticosteroids have not been universally effective in neutrophilic eccrine hidradenitis and confer more immunologic risks to the patient undergoing chemotherapy for treatment of malignancy. An individual with idiopathic neutrophilic eccrine hidradenitis was successfully treated with colchicine. [38] Generalized lesions in a child with idiopathic neutrophilic eccrine hidradenitis resolved in 2 weeks with topical steroid treatment. [39]

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Nonsteroidal anti-inflammatory drugs

Class Summary

Nonsteroidal anti-inflammatory drugs (NSAIDs) have analgesic and antipyretic activities. They inhibit cyclo-oxygenase activity and prostaglandin synthesis. Other mechanisms may exist as well, including inhibition of leukotriene synthesis, lysosomal enzyme release, lipoxygenase activity, neutrophil aggregation, and various cell-membrane functions.

Ibuprofen (Ibuprin, Advil, Motrin, Addaprin, Provil)

Ibuprofen is the drug of choice for mild to moderate pain. It inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis.

Ketoprofen

Ketoprofen is used for relief of mild to moderate pain and inflammation. Initially, small dosages are indicated in patients who are small and/or elderly and in those with renal or liver disease. Doses greater than 75 mg do not increase therapeutic effects. Administer high doses with caution, and closely observe the patient for response.

Naproxen (Anaprox, Naprelan, Naprosyn)

Naproxen is for relief of mild to moderate pain; it inhibits inflammatory reactions and pain by decreasing the activity of cyclo-oxygenase, which results in a decrease of prostaglandin synthesis.

Flurbiprofen

Flurbiprofen may inhibit the cyclo-oxygenase enzyme, which, in turn, inhibits prostaglandin biosynthesis. These effects may result in analgesic, antipyretic, and anti-inflammatory activities.

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