Bromhidrosis Medication

Updated: May 23, 2018
  • Author: Nathaniel Teegee, MD; Chief Editor: William D James, MD  more...
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Medication

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications.

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Antibacterial Agents

Class Summary

Bacteria have been implicated in the pathogenesis of bromhidrosis; the organisms decompose apocrine secretions, liberating fatty acids that have peculiar smells.

Clindamycin topical (Cleocin, Clindagel)

Clindamycin topical inhibits bacterial growth by binding to the 50S ribosomal subunit and blocking dissociation of peptidyl t-RNA from ribosomes, arresting RNA-dependent protein synthesis.

Erythromycin topical (Erythro-Statin 2%, Akne-mycin, Theramycin Z)

Erythromycin topical is a macrolide antimicrobial that inhibits bacterial growth by binding reversibly to the 50S ribosomal subunit and blocking dissociation of peptidyl t-RNA from ribosomes, arresting RNA-dependent protein synthesis. Use 2-4% solution.

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Neuromuscular Blocker Agent, Toxin

OnabotulinumtoxinA

OnabotulinumtoxinA is known to be effective in treating hyperhidrosis. It has also been found to decrease axillary odor in a study of healthy subjects and in one case study in genital bromhidrosis.

 

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Antiperspirant

Aluminum chloride topical

Aluminum chloride topical is an astringent agent used in the management of hyperhidrosis.  Its antiperspirant mechanism of action is not known, although creation of aluminum-containing casts within the sweat duct has been postulated. A solution of 20% aluminum chloride in ethyl alcohol is used.

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