Acne Conglobata Differential Diagnoses

Updated: Apr 05, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Diagnostic Considerations

Halogenoderma must be considered, especially iododerma and bromoderma. Similarly, the chlorinated chemical dioxin in high doses (eg, when used as a poison) can produce acneiform papulonodules resembling acne fulminans. [27]

Acne conglobata (AC) resembles acne fulminans because both cause numerous inflammatory nodules on the trunk. Acne conglobata produces polyporous comedones and noninflammatory cysts, while acne fulminans does not. Unlike acne conglobata, large nodules of acne fulminans tend to become painful ulcers with overhanging borders surrounding exudative necrotic plaques that become confluent.

Mycobacterium chelonae I infection has been described as a mimic of acne conglobata in an immunocompetent host. [28]

The SAPHO syndrome, of which acne conglobata may be a prominent component, may have spinal imaging findings that require distinction from infection and cancer. [24]

Acne conglobata has been described with trisomy 13 and selective IgM deficiency. [29]

Differential Diagnoses