Anetoderma Differential Diagnoses

Updated: Mar 01, 2022
  • Author: Anne Elizabeth Laumann, MBChB, MRCP(UK), FAAD; Chief Editor: Dirk M Elston, MD  more...
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Diagnostic Considerations

Anetoderma is one of several elastolytic disorders; others include cutis laxa, mid-dermal elastolysis, and granulomatous slack skin. Anetoderma is clinically recognized by well-demarcated saclike bulging when pandermal elastolysis is present. If the elastolysis is only partial, bulging may not be appreciated. Acquired cutis laxa differs from anetoderma by its generally widespread sagging or lax skin. Mid-dermal elastolysis is characterized by selective loss of elastic fibers in the mid dermis. This results in widespread fine wrinkling with or without perifollicular papules. Granulomatous slack skin is a rare variant of cutaneous T-cell lymphoma manifesting as erythematous pendulous folds of lax skin. It is histologically characterized by granulomas with phagocytosis of elastic fibers. [65]

Differential Diagnoses