Medication
Medication Summary
A 2002 report described effective treatment with topical tazarotene in two patients, [14] and a 2006 case study described imiquimod as an effective treatment after 10 weeks of therapy. [15]
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Retinoids
Tazarotene (Tazorac) cream or gel 0.05% or 0.1%
Tazarotene is a retinoid prodrug whose active metabolite modulates differentiation and proliferation of epithelial tissue; it may also have anti-inflammatory and immunomodulatory properties.
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Immune Modulators
Imiquimod (Aldara)
Imiquimod is an immune system modulator that stimulates the TH1 response. It up-regulates INF-alpha, INF-gamma, and IL-12. Currently, imiquimod is FDA approved for the treatment of genital warts, actinic keratoses, and superficial basal cell carcinomas. One case study in 2006 described it as an effective treatment after 10 weeks of therapy.
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Media Gallery
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Elastosis perforans serpiginosa in an arciform pattern on nape of neck.
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Advancing serpiginous arrangement of elastosis perforans serpiginosa papules with mild scarring in their wake.
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Histologic section of elastosis perforans serpiginosa stained with hematoxylin and eosin. Connective tissue fibers and cellular debris are extruded through the epidermis via a spiraling path.
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Cross-section of a nidus of fibers and debris of elastosis perforans serpiginosa in transit through the epidermis, stained with hematoxylin and eosin. Elastic fibers are red.
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Connective tissue and debris of elastosis perforans serpiginosa emerging through the epidermis toward the surface, and elastic fibers in the nearby papillary dermis. The stain is a variation on acid orcein-Giemsa. Elastic fibers are black.
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