Elastosis Perforans Serpiginosum Medication

Updated: Mar 06, 2019
  • Author: Elizabeth A Liotta, MD; Chief Editor: William D James, MD  more...
  • Print

Medication Summary

A 2002 report described effective treatment with topical tazarotene in two patients, [14] and a 2006 case study described imiquimod as an effective treatment after 10 weeks of therapy. [15]



Tazarotene (Tazorac) cream or gel 0.05% or 0.1%

Tazarotene is a retinoid prodrug whose active metabolite modulates differentiation and proliferation of epithelial tissue; it may also have anti-inflammatory and immunomodulatory properties.


Immune Modulators

Imiquimod (Aldara)

Imiquimod is an immune system modulator that stimulates the TH1 response. It up-regulates INF-alpha, INF-gamma, and IL-12. Currently, imiquimod is FDA approved for the treatment of genital warts, actinic keratoses, and superficial basal cell carcinomas. One case study in 2006 described it as an effective treatment after 10 weeks of therapy.