Kyrle Disease Workup

Updated: Apr 18, 2017
  • Author: Mary Piazza Maiberger, MD; Chief Editor: William D James, MD  more...
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Workup

Laboratory Studies

Examine blood glucose to evaluate for possible diabetes mellitus. Liver function studies are necessary in order to evaluate for possible underlying liver disease (eg, alcoholic cirrhosis). Perform renal function studies, including urinalysis, serum creatinine, and creatinine clearance, in order to evaluate for possible underlying renal disease.

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Histologic Findings

A partially parakeratotic plug, which fills an epidermal depression, is present. It may or may not involve a hair follicle. Marked acanthosis of surrounding epithelium usually is present. Within the plug, admixed basophilic debris often is present. Keratinous material extends focally from the basilar layer and may contact the dermis. At this point, necrotic cellular material and degenerated connective tissue are noted to undergo transepidermal elimination. A surrounding mixed infiltrate usually is present, including neutrophils, lymphocytes, and epithelioid histiocytes (macrophages).

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