Reactive Perforating Collagenosis Treatment & Management

Updated: Mar 07, 2017
  • Author: Rachel M Fisher, MBChB, MRCP; Chief Editor: Dirk M Elston, MD  more...
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Medical Care

Treatment of reactive perforating collagenosis lesions is often unsatisfactory; in many cases, the lesions are self-healing, but usually are recurrent.

Anecdotal reports describe successful therapy for reactive perforating collagenosis with retinoids, [17] allopurinol, [18, 16] doxycycline, [19] UVB, [20] and psoralen ultraviolet light A. [21] Phototherapy is a good choice for patients with coexistent renal disease and associated pruritus. Narrowband UVB phototherapy has been helpful in a case of familial reactive perforating collagenosis in a child. [22]

Topical steroids are usually not helpful, but intralesional steroids have been successful. [7]

Emollients and systemic antihistamines seem helpful in controlling pruritus.