Necrotizing Sialometaplasia Differential Diagnoses

Updated: Mar 14, 2023
  • Author: John A Svirsky, DDS, MEd; Chief Editor: Jeff Burgess, DDS, MSD  more...
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Diagnostic Considerations

Also consider the following:

  • Malignant salivary gland neoplasia
  • Benign salivary gland neoplasia
  • Lymphoma
  • Deep fungal Infections
  • Tuberculosis
  • Abscess
  • Oral lymphomatoid papulosis
  • Mucoepidermoid carcinoma
  • Subacute necrotizing sialadenitis

Necrotizing sialometaplasia has been misdiagnosed as a mucoepidermoid carcinoma, squamous cell carcinoma, acinic cell carcinoma, verrucous carcinoma, ductal carcinoma, mucus-producing adenocarcinoma, or mixed tumor.

In some cases, necrotizing sialometaplasia was misdiagnosed as pseudoepitheliomatous hyperplasia, a mucocele, or a pyogenic granuloma. Misdiagnosis can lead to significant adverse consequences for the patient. Necrotizing squamous metaplasia in herpetic tracheitis after prolonged intubation can simulate necrotizing sialometaplasia. [28]

Differential Diagnoses