Differential Diagnoses

Workup

Sugaya N, Martignago F, Pinto D, Migliari D. Recurrent Oral Eosinophilic Ulcers of the Oral Mucosa. A Case Report. Open Dent J. 2018. 12:19-23. [QxMD MEDLINE Link]. [Full Text].
Damevska K, Gocev G, Nikolovska S. Eosinophilic ulcer of the oral mucosa: report of a case with multiple synchronous lesions. Am J Dermatopathol. 2014 Jul. 36 (7):594-6. [QxMD MEDLINE Link].
Rahmatpour Rokni G, Sonthalia S, et al. Eosinophilic ulcer mimicking malignancy of the lower lip: A case report. Clin Case Rep. 2020 May. 8 (5):804-807. [QxMD MEDLINE Link]. [Full Text].
Dhanrajani P, Cropley PW. Oral eosinophilic or traumatic ulcer: A case report and brief review. Natl J Maxillofac Surg. 2015 Jul-Dec. 6 (2):237-40. [QxMD MEDLINE Link].
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Didona D, Paolino G, Donati M, et al. Eosinophilic ulcer of the tongue--Case report. An Bras Dermatol. 2015 May-Jun. 90 (3 Suppl 1):88-90. [QxMD MEDLINE Link]. [Full Text].
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Marszałek A, Neska-Długosz I. Traumatic ulcerative granuloma with stromal eosinophilia. A case report and short literature review. Pol J Pathol. 2011 Sep. 62 (3):172-5. [QxMD MEDLINE Link].
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Media Gallery

A 47-year-old African American woman with an eosinophilic ulcer on the lateral surface of the tongue. The anterior border of the lesion is raised. Courtesy of Dr Paul D. Freedman.
Raised, indurated, nonhealing ulcer on the lateral surface of the tongue. The lesion was related to an adjacent fractured tooth. Courtesy of Dr Paul D. Freedman.
Ulcer on the ventrolateral surface of the tongue. The differential diagnosis should include squamous cell carcinoma or an infectious etiology. Courtesy of Dr Paul D. Freedman.
Lesion on the lateral surface of the tongue. Courtesy of Dr Paul D. Freedman.
Low-power view showing an ulcerated surface epithelium with a dense cellular inflammatory infiltrate underlying the mucosal surface (original magnification X40). Courtesy of Dr Paul D. Freedman.
Cellular infiltrate composed mainly of large mononuclear cells, including histiocytes and submucosal dendrocytes, eosinophils, and scattered T lymphocytes (original magnification X400). Courtesy of Dr Paul D. Freedman.
Inflammatory infiltrate extending through and between muscle bundles (original magnification X400). Courtesy of Dr Paul D. Freedman.

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Author

Marc Zachary Handler, MD Fellow in Mohs Micrographic Surgery, Skin Laser and Surgery Specialists of NY and NJ

Marc Zachary Handler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, European Society for Pediatric Dermatology, International Society of Dermatology, New York Academy of Medicine, Sigma Xi, The Scientific Research Honor Society, Society for Pediatric Dermatology

Disclosure: Nothing to disclose.

Coauthor(s)

Paul D Freedman, DDS Director of Oral Pathology, New York Hospital Medical Center of Queens; Chief, Division of Oral Pathology and Oral Medicine, New York Presbyterian Hospital; Associate Professor of Surgery, Weill Cornell Medical College

Paul D Freedman, DDS is a member of the following medical societies: American Academy of Oral and Maxillofacial Pathology, American Dental Association

Disclosure: Nothing to disclose.

Specialty Editor Board

Michael J Wells, MD, FAAD Dermatologic/Mohs Surgeon, The Surgery Center at Plano Dermatology

Michael J Wells, MD, FAAD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, Texas Medical Association

Disclosure: Nothing to disclose.

Drore Eisen, MD, DDS Consulting Staff, Dermatology of Southwest Ohio

Drore Eisen, MD, DDS is a member of the following medical societies: American Academy of Dermatology, American Academy of Oral Medicine, American Dental Association

Disclosure: Nothing to disclose.

Chief Editor

Jeff Burgess, DDS, MSD (Retired) Clinical Assistant Professor, Department of Oral Medicine, University of Washington School of Dental Medicine; (Retired) Attending in Pain Center, University of Washington Medical Center; (Retired) Private Practice in Hawaii and Washington; Director, Oral Care Research Associates

Disclosure: Nothing to disclose.

Additional Contributors

Donald Belsito, MD Professor of Clinical Dermatology, Department of Dermatology, Columbia University Medical Center

Donald Belsito, MD is a member of the following medical societies: New York County Medical Society, Noah Worcester Dermatological Society, Phi Beta Kappa, American Contact Dermatitis Society, Dermatology Foundation, Dermatologic Society of Greater New York, Alpha Omega Alpha, American Academy of Dermatology

Disclosure: Nothing to disclose.

Faizan Alawi, DDS Associate Professor, Department of Pathology, Penn Dental Medicine, University of Pennsylvania School of Dental Medicine; Associate Professor, Department of Dermatology, Section of Dermatopathology, Hospital of the University of Pennsylvania

Faizan Alawi, DDS is a member of the following medical societies: American Academy of Oral and Maxillofacial Pathology, International Association for Dental Research

Disclosure: Nothing to disclose.

Eosinophilic Ulcer Differential Diagnoses

Differential Diagnoses

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