Cheilitis Glandularis Medication

Updated: Sep 06, 2018
  • Author: Ellen Eisenberg, DMD; Chief Editor: William D James, MD  more...
  • Print
Medication

Medication Summary

For cases attributable to angioedema, administration of an antihistamine may effect temporary reduction in acute nonpurulent swelling. Suppurative cases of cheilitis glandularis require management with appropriate antimicrobial treatment as determined by culture and sensitivity testing. Concomitant intralesional or oral corticosteroid treatment may potentiate the effectiveness of antimicrobial therapy in cases with significant nodularity; however, potential systemic adverse effects of long-term corticosteroid treatment, plus propensity for promoting local fibrosis and scarring, limit its potential use either as an adjunct to antibiotic treatment or as a single therapeutic modality for cheilitis glandularis.

Topical 5-fluorouracil is useful for the treatment of dysplastic actinic cheilitis and to curtail its progression. In conjunction with clinical supervision, it can be prescribed as an alternative to vermilionectomy or as a prophylactic measure following vermilionectomy.

Next:

Antihistamines

Class Summary

These agents are used to treat angioedema or suspected allergic reaction.

Diphenhydramine (Benadryl)

Diphenhydramine is used for symptomatic relief of symptoms caused by the release of histamine in allergic reactions.

Previous
Next:

Pyrimidine antagonists

Class Summary

These agents are used to treat actinic cheilitis (dysplastic).

Fluorouracil topical (Efudex, Fluoroplex, Carac)

Fluorouracil topical interferes with DNA synthesis by blocking the methylation of deoxyuridylic acid, inhibiting thymidylate synthetase and subsequently cell proliferation. Topical forms are approved for actinic keratoses; only the 5% (Efudex) form is approved for superficial basal cell carcinoma.

Previous
Next:

Corticosteroids

Class Summary

These agents have anti-inflammatory properties and cause profound and varied metabolic effects. They modify the body's immune response to diverse stimuli.

Prednisone (Deltasone, Orasone)

Prednisone is an immunosuppressant for the treatment of autoimmune disorders; it may decrease inflammation by reversing increased capillary permeability and suppressing PMN activity. Prednisone stabilizes lysosomal membranes and suppresses lymphocyte and antibody production. A single morning dose is safer for long-term use, but divided doses have more anti-inflammatory effect.

Previous