DDx
Diagnostic Considerations
The most recent diagnostic criteria has been proposed by Ordioni et al [30] where a minimum of 6 out of 9 criteria should be met:
Table (Open Table in a new window)
Main criteria |
(I) Clinically noticeable hemorrhagic bulla or erosion with a history of bleeding of the oral mucosa |
(II) Exclusively oral or oropharyngeal localization |
Additional criteria |
(III) Palatal localization |
(IV) Triggering event or promoting factor (food intake) |
(V) Recurrent lesions |
(VI) Favorable evolution without leaving a scar in a few days |
(VII) Painless lesion, tingling, or burning sensation |
(VIII) Normal platelet count and coagulation profile |
(IX) Negative direct immunofluorescence |
Differential Diagnoses
-
Bullous erythema multiforme
-
Bullous lichen planus
-
Fixed Drug Eruptions
-
Pemphigus
Media Gallery
-
A 42-year-old man with the sudden appearance of angina bullosa hemorrhagica. The patient experienced pain a few minutes before the bulla appeared. He had a history of 3 similar previous episodes at the same site. Because the lesions only stay intact for a short duration, the patient took the picture using his own cellular phone.
-
A 42-year-old man with the sudden appearance of angina bullosa hemorrhagica. The patient experienced pain a few minutes before the bulla appeared. He had a history of 3 similar previous episodes at the same site. Because the lesions only stay intact for a short duration, the patient took the picture using his own cellular phone. Image shows 24 hours after the initial presentation of angina bullosa hemorrhagica.
of
2