Oral Neurofibroma Differential Diagnoses

Updated: Jun 19, 2018
  • Author: Indraneel Bhattacharyya, DDS, MSD; Chief Editor: Jeff Burgess, DDS, MSD  more...
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Diagnostic Considerations

Also consider the following:

  • Granular cell tumor
  • Fibroma
  • Scar tissue
  • Neurilemmoma (schwannoma)
  • Leiomyoma
  • Rhabdomyoma
  • Other benign mesenchymal entities

Diffuse neurofibroma (as sometimes seen with neurofibromatosis) may involve the tongue, resulting in macroglossia that may require differentiation from amyloidosis and lymphangioma.

A solitary neurofibroma may be a precursor to neurofibromatosis (also see Neurofibromatosis, Type 1), and the patient should be evaluated with this in mind. Close clinical follow up and/or genetic testing may be required, especially if a lesion recurs multiple times or more than one lesion is seen.

Differential Diagnoses