Oral Hemangiomas Medication

Updated: Mar 21, 2018
  • Author: Steven Brett Sloan, MD; Chief Editor: William D James, MD  more...
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Medication

Medication Summary

No medications, other than those used for initial treatment, are needed. For patients with an asymptomatic oral vascular malformation that is stable, nonprogressive, and that has no functional impairment or bleeding, observation is indicated. Painful perioral hemangiomas may manifest as difficult feeding and failure to thrive. Topical lidocaine-containing preparations, acetaminophen, and codeine have all been used for pain control. Smidt and Strand reported a painful hemangioma controlled with over-the-counter Orabase. Orabase contains 20% benzocaine, and possible adverse effects include allergic contact dermatitis and methemoglobinemia. [63]

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Corticosteroids

Class Summary

Steroids have become a mainstay in the treatment of proliferating hemangiomas in infants and children. These agents have anti-inflammatory properties and cause profound and varied metabolic effects. They modify the body's immune response to diverse stimuli.

Prednisone (Meticorten, Orasone, Deltasone, Sterapred)

Prednisone is an immunosuppressant for the treatment of autoimmune disorders; it may decrease inflammation by reversing increased capillary permeability and suppressing PMN activity. Prednisone stabilizes lysosomal membranes and suppresses lymphocyte and antibody production.

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Interferons

Class Summary

These agents are naturally produced proteins with antiviral, antitumor, and immunomodulatory actions. Alpha, beta, and gamma interferons may be given topically, systemically, and intralesionally.

Interferon alfa-2b (Intron-A)

Interferon alfa-2b is a protein product manufactured by recombinant DNA technology. Its mechanism of antitumor activity is not clearly understood; however, direct antiproliferative effects against malignant cells and modulation of host immune response may play important roles.

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Antihypertensive Agent

Propranolol

Propranolol hydrochloride is a synthetic nonselective beta-adrenergic receptor blocking agent. A generic form is available as 10-, 20-, 40-, 60-, and 80-mg tablets and as 60-, 80-, 120-, and 180-mg extended-release tablets. Inderal is available as 10-, 20-, 40-, 60-, and 80-mg tablets for oral administration. InnoPran XL is available as 80- and 120-mg extended-release tablets. No commercially available liquid formulation is available for use in children and must be formulated by a qualified pharmacist. It is indicated for hypertension and a variety of other cardiac conditions (angina) and migraine headache prophylaxis.

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Anesthetics, Oropharyngeal

Benzocaine

Benzocaine is a PABA derivative ester-type local anesthetic that is minimally absorbed. It inhibits neuronal membrane depolarization, blocking nerve impulses. It is used to control pain.

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