Oral Florid Papillomatosis Differential Diagnoses

Updated: May 28, 2019
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
  • Print

Diagnostic Considerations

Histopathological differential diagnosis of verrucous hyperplasia, verrucous keratosis, and verrucous carcinoma can be challenging in small or superficial biopsy specimens [44, 45] and even incisional biopsy specimens. [46]

Verrucous hyperplasia of the oral mucosa and verruca vulgaris should also be considered.

Proliferative verrucous leukoplakia is a rare oral mucosa disorder that may progress to oral squamous cell carcinoma. [47, 48] It can be viewed as an aggressive form of oral leukoplakia with a high rate of recurrence and malignant potential. [49] It affects mainly adult/elderly women and does not correlate with the major risk factors for oral carcinoma. [50]

Differential Diagnoses