Erythema Gyratum Repens Workup

Updated: Mar 27, 2019
  • Author: Nicole Ufkes; Chief Editor: Dirk M Elston, MD  more...
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Laboratory Studies

A basic workup is warranted when approaching a patient with erythema gyratum repens to search for common or clinically suspected malignancies. This includes the following:

  • Complete physical examination (including pelvic examination and Papanicolaou test [Pap smear] for women, prostate examination and prostate-specific antigen test for men)

  • Urinalysis

  • Basic hematologic panel

  • Blood chemistries (including liver function test, calcium, phosphorus, total protein)

  • Stool guaiac and/or Hemoccult test


Imaging Studies

Examine patients with erythema gyratum repens for common or clinically suspected malignancies. This workup can include chest radiography and CT scanning of the abdomen and pelvis.



Necessary procedures may include the following:

  • Esophagogastroduodenoscopy

  • Ear, nose, and throat examination (for malignancy)


Histologic Findings

The primary finding is mild spongiosis, focal parakeratosis, and a superficial perivascular lymphohistiocytic infiltrate that also may include eosinophils and melanophages. Exocytosis of neutrophils and eosinophils may be observed. Direct immunofluorescence tests sometimes reveal C3, C4, and immunoglobulin G at the basement membrane zone. [32]