Cold Panniculitis Differential Diagnoses

Updated: Apr 06, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
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Diagnostic Considerations

See the list below:

  • Cold panniculitis neonatorum synonymous with adiponecrosis subcutanea

  • Sclerema neonatorum synonymous with sclerema adiposum neonatorum

  • Chilblain

  • Lupus erythematosus panniculitis [13]

  • Lymphoma cutis [14]

  • Neutrophilic panniculitis [15]

  • Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis [16]

Differential diagnosis also includes poststeroid panniculitis and frostbite. [17]

Cytophagic histiocytic panniculitis often presents with multiple subcutaneous nodules and eventuates in a bleeding diathesis. [18]

In endemic areas, cutaneous leishmaniasis may occasionally be part of the differential diagnosis. [19]

Equestrian perniosis is a rare disorder that appears as tender burning nodular plaques on bilateral thighs after riding in the cold; it tends to promptly resolve and has no known significant systemic disease associations. [20] It is histologically characterized by perivascular lymphocytic infiltrate that prominently involves the fat. Equestrian chilblain is also known as equestrian cold panniculitis. [21]

Familial chilblain lupus may be due to a novel mutation in the exonuclease III domain of 3' repair exonuclease 1 (TREX1). [22, 23]

Subcutaneous panniculitis‒like T-cell lymphoma is also in the differential diagnosis. [24, 25]

Differential Diagnoses